Background: The expression of matrix metalloproteinases 2/9 (MMP-2/9) has been
implicated in arterial remodeling and inflammation in atherosclerosis. We evaluated a …

Objective: Vascular injury causes neointimal hypertrophy, which is characterized by redox-
mediated matrix degradation and smooth muscle cell (SMC) migration and proliferation. We …

Angiogenesis is described as a sprouting and growth process of new blood vessels from pre-
existing vasculature. The relationship between angiogenesis and coronary artery disease …

To test our hypothesis that erythrocytes may induce plaque vulnerability and investigate the
mechanism involved, we established a novel model of intraplaque hemorrhage in 56 New …

Atherosclerosis, the main cause of heart attack and stroke, is the leading cause of death in
most modern countries. Preventing clinical events depends on a better understanding of the …

Objective—The protein degrading activity of cathepsin C (CatC), combined with its role in
leukocyte granule activation, suggests a contribution of this cystein protease in …

Erythropoietin (EPO), a type I cytokine originally identified for its critical role in
hematopoiesis, has been shown to have non-hematopoietic, tissue-protective effects …

目的观察解毒活血中药配伍对载脂蛋白E 基因敲除小鼠[apolipoprotein E knocked-out mice,
ApoE (-/-) mice] 主动脉核因子-κB (NF-κB) 和基质金属蛋白酶-9 (MMP-9) 表达水平的调控作用 …

Background and aim Adipose tissue produces different metalloproteinases (MMPs),
involved in adipogenesis and angiogenesis. Different studies have shown that in obesity the …