Bidirectional relationships of comorbidity with obstructive sleep apnoea

M Gleeson, WT McNicholas - European respiratory review, 2022 - Eur Respiratory Soc
Obstructive sleep apnoea (OSA) is frequently associated with comorbidities that include
metabolic, cardiovascular, renal, pulmonary and neuropsychiatric. There is considerable …

Obstructive sleep apnea: transition from pathophysiology to an integrative disease model

WT McNicholas, D Pevernagie - Journal of sleep research, 2022 - Wiley Online Library
Obstructive sleep apnea (OSA) is characterised by recurring episodes of upper airway
obstruction during sleep and the fundamental abnormality reflects the inability of the upper …

Obstructive sleep apnea and stroke: the mechanisms, the randomized trials, and the road ahead

S Javaheri, Y Peker, HK Yaggi, CLA Bassetti - Sleep medicine reviews, 2022 - Elsevier
When considered separately from cardiovascular disease, stroke is the third leading cause
of death in the US and is the leading cause of long-term disability in adults. New approaches …

Sleep patterns and the risk of acute stroke: results from the INTERSTROKE international case-control study

CE Mc Carthy, S Yusuf, C Judge, A Alvarez-Iglesias… - Neurology, 2023 - AAN Enterprises
Background and Objectives Symptoms of sleep disturbance are common and may represent
important modifiable risk factors of stroke. We evaluated the association between a spectrum …

Effect of high-risk obstructive sleep apnea on clinical outcomes in adults with coronavirus disease 2019: a multicenter, prospective, observational clinical trial

Y Peker, Y Celik, S Arbatli, SR Isik… - Annals of the …, 2021 - atsjournals.org
Rationale: Coronavirus disease (COVID-19) is an ongoing pandemic, in which obesity,
hypertension, and diabetes have been linked to poor outcomes. Obstructive sleep apnea …

[HTML][HTML] Obstructive sleep apnea aggravates neuroinflammation and pyroptosis in early brain injury following subarachnoid hemorrhage via ASC/HIF-1α pathway

J Xu, Q Li, CY Xu, S Mao, JJ Jin, W Gu… - Neural Regeneration …, 2022 - journals.lww.com
Obstructive sleep apnea can worsen the prognosis of subarachnoid hemorrhage. However,
the underlying mechanism remains unclear. In this study, we established a mouse model of …

[HTML][HTML] Regular snoring is associated with uncontrolled hypertension

B Lechat, G Naik, S Appleton, J Manners, H Scott… - npj Digital …, 2024 - nature.com
Snoring may be a risk factor for cardiovascular disease independent of other co-morbidities.
However, most prior studies have relied on subjective, self-report, snoring evaluation. This …

Randomized clinical trials of cardiovascular disease in obstructive sleep apnea: understanding and overcoming bias

RD McEvoy, M Sánchez-de-la-Torre, Y Peker… - Sleep, 2021 - academic.oup.com
In their recent provocative commentary, Pack et al.[1] contend that the neutral results of
randomized controlled trials (RCTs) of continuous positive airways pressure (CPAP) for …

Up-to-date advance in the relationship between OSA and stroke: a narrative review

B Sun, Q Ma, J Shen, Z Meng, J Xu - Sleep and Breathing, 2024 - Springer
Purpose Obstructive sleep apnea (OSA) and stroke affect each other. In this review, we
summarized the effect of OSA on the onset and recurrence of stroke, the prognosis, and the …

Australasian Sleep Association position statement on consensus and evidence based treatment for primary snoring

LM Sarkis, AC Jones, A Ng, C Pantin, SL Appleton… - …, 2023 - Wiley Online Library
Primary snoring impacts a significant portion of the adult population and has the potential to
significantly impair quality of life. The purpose of these guidelines is to provide evidence …