The main protease of SARS-CoV-2 is one of the important targets to design and develop
antiviral drugs. In this study, we have selected 40 antiviral phytochemicals to find out the …

Abstract New sulfonamides 5/6 derived from 4-methoxyacetophenone 1 were synthesized
by N-sulfonation reaction of ammonia (3) and aminopyrimidinone (4) with its sulfonyl …

Abstract Type 2 diabetes (T2D) is generally characterized by elevated blood glucose levels,
insulin resistance, and relative lack of insulin; however, insulin resistance is the predominant …

Botrytis cinerea is considered an important plant pathogen and is responsible for significant
crop yield losses. With the frequent application of commercial fungicides, B. cinerea has …

BACKGROUND Plant disease is one of the most serious problems in agriculture that can
damage crops. Chemical fungicides are widely used to control plant diseases, but have led …

Thirty-four novel compounds were synthesized using chesulfamide (N-(2-trifluoromethyl-4-
chlorophenyl)-2-oxocyclohexyl sulfonamide), a high-profile fungicide, as the lead …

Botrytis cinerea is an economically important fungal pathogen with a host range of over 200
plant species. Unfortunately, gray mold disease caused by B. cinerea has not been …

N-(2-trifluoromethyl-4-chlorophenyl)-2-oxocyclohexyl sulfonamide (chesulfamide) is in the
limelight as a novel fungicide, and has fungicidal activity against Botrytis cinerea. For …

In viral binding and entry, the Spike (S) protein of SARS-CoV-2 uses transmembrane serine
protease 2 (TMPRSS2) for priming to cleavage themselves. In this study, we have screened …

To develop more valuable and effective fungicide candidates, a novel series of 3, 4-
dichloroisothioxazole-based cycloalkylsulfonamides were synthesized and their structures …