Exploiting innate immunity for cancer immunotherapy
M Yi, T Li, M Niu, Q Mei, B Zhao, Q Chu, Z Dai, K Wu - Molecular cancer, 2023 - Springer
Immunotherapies have revolutionized the treatment paradigms of various types of cancers.
However, most of these immunomodulatory strategies focus on harnessing adaptive …
However, most of these immunomodulatory strategies focus on harnessing adaptive …
A comprehensive overview on antibody-drug conjugates: from the conceptualization to cancer therapy
F Riccardi, M Dal Bo, P Macor, G Toffoli - Frontiers in Pharmacology, 2023 - frontiersin.org
Antibody-Drug Conjugates (ADCs) represent an innovative class of potent anti-cancer
compounds that are widely used in the treatment of hematologic malignancies and solid …
compounds that are widely used in the treatment of hematologic malignancies and solid …
A Hybrid Nanoadjuvant Simultaneously Depresses PD‐L1/TGF‐β1 and Activates cGAS‐STING Pathway to Overcome Radio‐Immunotherapy Resistance
Currently, certain cancer patients exhibit resistance to radiotherapy due to reduced DNA
damage under hypoxic conditions and acquired immune tolerance triggered by transforming …
damage under hypoxic conditions and acquired immune tolerance triggered by transforming …
Mechanoregulatory Cholesterol Oxidase‐Functionalized Nanoscale Metal–Organic Framework Stimulates Pyroptosis and Reinvigorates T Cells
Cancer cells alter mechanical tension in their cell membranes. New interventions to regulate
cell membrane tension present a potential strategy for cancer therapy. Herein, the increase …
cell membrane tension present a potential strategy for cancer therapy. Herein, the increase …
Low-dose non-targeted effects and mitochondrial control
D Averbeck - International Journal of Molecular Sciences, 2023 - mdpi.com
Non-targeted effects (NTE) have been generally regarded as a low-dose ionizing radiation
(IR) phenomenon. Recently, regarding long distant abscopal effects have also been …
(IR) phenomenon. Recently, regarding long distant abscopal effects have also been …
Dismantlable coronated nanoparticles for coupling the induction and perception of immunogenic cell death
H Liang, C Xu, D Guo, F Peng, N Chen… - Advanced …, 2024 - Wiley Online Library
Therapy‐induced immunogenic cell death (ICD) can initiate both innate and adaptive
immune responses for amplified anti‐tumor efficacy. However, dying cell‐released ICD …
immune responses for amplified anti‐tumor efficacy. However, dying cell‐released ICD …
Nanoparticle-integrated dissolving microneedles for the co-delivery of R848/aPD-1 to synergistically reverse the immunosuppressive microenvironment of triple …
S Huang, T Wen, J Wang, H Wei, Z Xiao, B Li, X Shuai - Acta Biomaterialia, 2024 - Elsevier
Nowadays, effective immunotherapy against triple-negative breast cancer (TNBC) remains
challenging due to the immunosuppressive tumor microenvironment. Immune checkpoint …
challenging due to the immunosuppressive tumor microenvironment. Immune checkpoint …
Effects of chemotherapy on the immune system: Implications for cancer treatment and patient outcomes
A Sharma, S Jasrotia, A Kumar - Naunyn-Schmiedeberg's Archives of …, 2024 - Springer
Chemotherapy is a cornerstone of cancer treatment, but it can also induce immune
suppression, which can have significant implications for patient outcomes. This review paper …
suppression, which can have significant implications for patient outcomes. This review paper …
The implications of FASN in immune cell biology and related diseases
Y Xiao, Y Yang, H Xiong, G Dong - Cell Death & Disease, 2024 - nature.com
Fatty acid metabolism, particularly fatty acid synthesis, is a very important cellular
physiological process in which nutrients are used for energy storage and biofilm synthesis …
physiological process in which nutrients are used for energy storage and biofilm synthesis …
[HTML][HTML] Inhibition of CSF-1R and IL-6R prevents conversion of cDC2s into immune incompetent tumor-induced DC3s boosting DC-driven therapy potential
AMD Becker, AH Decker, G Flórez-Grau, G Bakdash… - Cell Reports …, 2024 - cell.com
The human dendritic cell (DC) family has recently been expanded by CD1c+ CD14+
CD163+ DCs, introduced as DC3s. DC3s are found in tumors and peripheral blood of …
CD163+ DCs, introduced as DC3s. DC3s are found in tumors and peripheral blood of …