Exploiting innate immunity for cancer immunotherapy

M Yi, T Li, M Niu, Q Mei, B Zhao, Q Chu, Z Dai, K Wu - Molecular cancer, 2023 - Springer
Immunotherapies have revolutionized the treatment paradigms of various types of cancers.
However, most of these immunomodulatory strategies focus on harnessing adaptive …

A comprehensive overview on antibody-drug conjugates: from the conceptualization to cancer therapy

F Riccardi, M Dal Bo, P Macor, G Toffoli - Frontiers in Pharmacology, 2023 - frontiersin.org
Antibody-Drug Conjugates (ADCs) represent an innovative class of potent anti-cancer
compounds that are widely used in the treatment of hematologic malignancies and solid …

A Hybrid Nanoadjuvant Simultaneously Depresses PD‐L1/TGF‐β1 and Activates cGAS‐STING Pathway to Overcome Radio‐Immunotherapy Resistance

L Yi, X Jiang, Z Zhou, W Xiong, F Xue, Y Liu… - Advanced …, 2024 - Wiley Online Library
Currently, certain cancer patients exhibit resistance to radiotherapy due to reduced DNA
damage under hypoxic conditions and acquired immune tolerance triggered by transforming …

Mechanoregulatory Cholesterol Oxidase‐Functionalized Nanoscale Metal–Organic Framework Stimulates Pyroptosis and Reinvigorates T Cells

W Zhen, T Luo, Z Wang, X Jiang, E Yuan… - Small, 2023 - Wiley Online Library
Cancer cells alter mechanical tension in their cell membranes. New interventions to regulate
cell membrane tension present a potential strategy for cancer therapy. Herein, the increase …

Low-dose non-targeted effects and mitochondrial control

D Averbeck - International Journal of Molecular Sciences, 2023 - mdpi.com
Non-targeted effects (NTE) have been generally regarded as a low-dose ionizing radiation
(IR) phenomenon. Recently, regarding long distant abscopal effects have also been …

Dismantlable coronated nanoparticles for coupling the induction and perception of immunogenic cell death

H Liang, C Xu, D Guo, F Peng, N Chen… - Advanced …, 2024 - Wiley Online Library
Therapy‐induced immunogenic cell death (ICD) can initiate both innate and adaptive
immune responses for amplified anti‐tumor efficacy. However, dying cell‐released ICD …

Nanoparticle-integrated dissolving microneedles for the co-delivery of R848/aPD-1 to synergistically reverse the immunosuppressive microenvironment of triple …

S Huang, T Wen, J Wang, H Wei, Z Xiao, B Li, X Shuai - Acta Biomaterialia, 2024 - Elsevier
Nowadays, effective immunotherapy against triple-negative breast cancer (TNBC) remains
challenging due to the immunosuppressive tumor microenvironment. Immune checkpoint …

Effects of chemotherapy on the immune system: Implications for cancer treatment and patient outcomes

A Sharma, S Jasrotia, A Kumar - Naunyn-Schmiedeberg's Archives of …, 2024 - Springer
Chemotherapy is a cornerstone of cancer treatment, but it can also induce immune
suppression, which can have significant implications for patient outcomes. This review paper …

The implications of FASN in immune cell biology and related diseases

Y Xiao, Y Yang, H Xiong, G Dong - Cell Death & Disease, 2024 - nature.com
Fatty acid metabolism, particularly fatty acid synthesis, is a very important cellular
physiological process in which nutrients are used for energy storage and biofilm synthesis …

[HTML][HTML] Inhibition of CSF-1R and IL-6R prevents conversion of cDC2s into immune incompetent tumor-induced DC3s boosting DC-driven therapy potential

AMD Becker, AH Decker, G Flórez-Grau, G Bakdash… - Cell Reports …, 2024 - cell.com
The human dendritic cell (DC) family has recently been expanded by CD1c+ CD14+
CD163+ DCs, introduced as DC3s. DC3s are found in tumors and peripheral blood of …