Cancer and neurodegenerative diseases are caused by genetic and environmental factors.
Expression of tumour suppressor genes is suppressed by mutations or epigenetic silencing …

DNA is a strikingly flexible molecule and can form a variety of secondary structures,
including the triple helix, which is the subject of this review. The DNA triplex may be formed …

DNA forms not only the canonical duplex structure but also non-canonical structures. Most
potential sequences that induce the formation of non-canonical structures are present in …

The existence of sequences in the human genome which can be a target for triplex
formation, and accordingly are candidates for anti‐gene therapies, has been studied by …

DNA triple-helix-based approaches to control and modulate cellular functions on the level of
genomic DNA (antigene technology) suffered in the past from a stepmother-like treatment in …

We have achieved recognition of all 4 bp by triple helix formation at physiological pH, using
triplex-forming oligonucleotides that contain four different synthetic nucleotides. BAU [2 …

Specific cleavage of large DNA molecules at few sites, necessary for the analysis of
genomic DNA or for targeting individual genes in complex genomes, requires …

Newcomers to the field of biopharmaceuticals require an understanding of the basic
principles and underlying methodology involved in developing protein-and nucleic acid …

Cancer diagnosis continuously evolves due to the better understanding of tumorigenic
processes. DNA-methylation is consolidated as an effective biomarker for cancer prognosis …

A DNA structure, known as triple-stranded DNA, is made up of three oligonucleotide chains
that wind around one another to form a triple helix (TFO). Hoogsteen base pairing describes …