Red Queen host–parasite co-evolution can drive adaptations of immune genes by positive
selection that erodes genetic variation (Red Queen arms race) or results in a balanced …

In a pair of articles, we present a generalized quantitative model for the homeostatic function
of clonal humoral immune system. In this second paper, we describe how antibody …

B cell epitope prediction methods are separated into linear sequence-based predictors and
conformational epitope predictions that typically use the measured or predicted protein …

The homeostasis of antibodies can be characterized as a balanced production, target‐
binding and receptor‐mediated elimination regulated by an interaction network, which …

Antibodies constitute a major component of serum on protein mass basis. We also know that
the structural diversity of these antibodies exceeds that of all other proteins in the body and …

Adaptive immunity in vertebrates is a complex self-organizing network of molecular
interactions. While deep sequencing of the immune-receptor repertoire may reveal clonal …

Abstract Background Interleukin-2 (IL-2) and soluble CD25 (sCD25) are among the most
important cytokines and diagnostic biomarkers in hemophagocytic lymphohistiocytosis …

The humoral adaptive immune system, from the physical perspective, can be regarded as a
self-organized antibody binding energy landscape. In biological terms it means the system …

Antigen specific humoral immunity can be characterized by the analysis of serum antibodies.
While serological assays for the measurement of antibody levels and of neutralization …

Physical modeling of the functioning of the adaptive immune system, which has been
thoroughly characterized on genetic and molecular levels, provides a unique opportunity to …