Polycythemia vera: 2024 update on diagnosis, risk‐stratification, and management
Abstract Disease Overview Polycythemia vera (PV) is a JAK2‐mutated myeloproliferative
neoplasm characterized by clonal erythrocytosis; other features include leukocytosis …
neoplasm characterized by clonal erythrocytosis; other features include leukocytosis …
Essential thrombocythemia: 2024 update on diagnosis, risk stratification, and management.
Essential thrombocythemia is a Janus kinase 2 (JAK2) mutation-prevalent myeloproliferative
neoplasm characterized by clonal thrombocytosis; clinical course is often indolent but might …
neoplasm characterized by clonal thrombocytosis; clinical course is often indolent but might …
Moving toward disease modification in polycythemia vera
JP Bewersdorf, J How, L Masarova, P Bose… - Blood, 2023 - ashpublications.org
Polycythemia vera (PV) belongs to the BCR-ABL1–negative myeloproliferative neoplasms
and is characterized by activating mutations in JAK2 and clinically presents with …
and is characterized by activating mutations in JAK2 and clinically presents with …
ROP-ET: a prospective phase III trial investigating the efficacy and safety of ropeginterferon alfa-2b in essential thrombocythemia patients with limited treatment …
JJ Kiladjian, FF Marin, HK Al-Ali, A Alvarez-Larrán… - Annals of …, 2024 - Springer
Interferon-based therapies, such as ropeginterferon alfa-2b have emerged as promising
disease-modifying agents for myeloproliferative neoplasms (MPNs), including essential …
disease-modifying agents for myeloproliferative neoplasms (MPNs), including essential …
Ropeginterferon phase 2 randomized study in low-risk polycythemia vera: 5-year drug survival and efficacy outcomes
In patients with low-risk polycythemia vera, exposure to low-dose Ropeginterferon alfa-2b
(Ropeg) 100 µg every 2 weeks for 2 years was more effective than the standard treatment of …
(Ropeg) 100 µg every 2 weeks for 2 years was more effective than the standard treatment of …
Neutrophil/lymphocyte ratio identifies low‐risk polycythaemia vera patients for early Ropeginterferon alfa‐2b therapy
We investigated the effect of Ropeginterferon alfa‐2b (Ropeg) versus phlebotomy‐only (Phl‐
O) on the neutrophil‐to‐lymphocyte ratio (NLR) in 126 patients randomized in the low …
O) on the neutrophil‐to‐lymphocyte ratio (NLR) in 126 patients randomized in the low …
Ethnic sensitivity analyses of pharmacokinetics, efficacy and safety in polycythemia vera treatment with ropeginterferon alfa-2b
A Qin, D Wu, J Liao, S Xie, H Chen, Y Gao… - Frontiers in …, 2024 - frontiersin.org
Ropeginterferon alfa-2b (Ropeg) is approved for the treatment of adults with polycythemia
vera (PV). This report aims to analyze the ethnic sensitivity of Ropeg for the treatment of PV …
vera (PV). This report aims to analyze the ethnic sensitivity of Ropeg for the treatment of PV …
Ropeginterferon alfa-2b shows anti-polycythaemia vera activity without causing clinically significant anaemia
K Kirito, A Qin, S Suo, R Fu, D Wu, T Sato… - BJC Reports, 2024 - nature.com
Anaemia could develop in polycythemia vera (PV) due to phlebotomy-caused iron-
deficiency and cytotoxic effect of cytoreductive therapy. Ropeginterferon alfa-2b treatment …
deficiency and cytotoxic effect of cytoreductive therapy. Ropeginterferon alfa-2b treatment …
Cost–effectiveness of ropeginterferon alfa-2b-njft for the treatment of polycythemia vera
AT Gerds, C Castro, F Snopek… - Journal of …, 2023 - becarispublishing.com
Aim: Patients with polycythemia vera (PV), a rare and chronic blood cancer, are at a higher
risk for thromboembolic events, progression to myelofibrosis, and leukemic transformation …
risk for thromboembolic events, progression to myelofibrosis, and leukemic transformation …
Interferons in the treatment of myeloproliferative neoplasms
P Vachhani, J Mascarenhas, P Bose… - Therapeutic …, 2024 - journals.sagepub.com
Interferons are cytokines with immunomodulatory properties and disease-modifying effects
that have been used to treat myeloproliferative neoplasms (MPNs) for more than 35 years …
that have been used to treat myeloproliferative neoplasms (MPNs) for more than 35 years …