Polycythemia vera: 2024 update on diagnosis, risk‐stratification, and management

A Tefferi, T Barbui - American journal of hematology, 2023 - Wiley Online Library
Abstract Disease Overview Polycythemia vera (PV) is a JAK2‐mutated myeloproliferative
neoplasm characterized by clonal erythrocytosis; other features include leukocytosis …

Essential thrombocythemia: 2024 update on diagnosis, risk stratification, and management.

A Tefferi, AM Vannucchi, T Barbui - American journal of hematology, 2024 - europepmc.org
Essential thrombocythemia is a Janus kinase 2 (JAK2) mutation-prevalent myeloproliferative
neoplasm characterized by clonal thrombocytosis; clinical course is often indolent but might …

Moving toward disease modification in polycythemia vera

JP Bewersdorf, J How, L Masarova, P Bose… - Blood, 2023 - ashpublications.org
Polycythemia vera (PV) belongs to the BCR-ABL1–negative myeloproliferative neoplasms
and is characterized by activating mutations in JAK2 and clinically presents with …

ROP-ET: a prospective phase III trial investigating the efficacy and safety of ropeginterferon alfa-2b in essential thrombocythemia patients with limited treatment …

JJ Kiladjian, FF Marin, HK Al-Ali, A Alvarez-Larrán… - Annals of …, 2024 - Springer
Interferon-based therapies, such as ropeginterferon alfa-2b have emerged as promising
disease-modifying agents for myeloproliferative neoplasms (MPNs), including essential …

Ropeginterferon phase 2 randomized study in low-risk polycythemia vera: 5-year drug survival and efficacy outcomes

T Barbui, A Carobbio, V De Stefano… - Annals of …, 2024 - Springer
In patients with low-risk polycythemia vera, exposure to low-dose Ropeginterferon alfa-2b
(Ropeg) 100 µg every 2 weeks for 2 years was more effective than the standard treatment of …

Neutrophil/lymphocyte ratio identifies low‐risk polycythaemia vera patients for early Ropeginterferon alfa‐2b therapy

T Barbui, A Carobbio, P Guglielmelli… - British Journal of …, 2024 - Wiley Online Library
We investigated the effect of Ropeginterferon alfa‐2b (Ropeg) versus phlebotomy‐only (Phl‐
O) on the neutrophil‐to‐lymphocyte ratio (NLR) in 126 patients randomized in the low …

Ethnic sensitivity analyses of pharmacokinetics, efficacy and safety in polycythemia vera treatment with ropeginterferon alfa-2b

A Qin, D Wu, J Liao, S Xie, H Chen, Y Gao… - Frontiers in …, 2024 - frontiersin.org
Ropeginterferon alfa-2b (Ropeg) is approved for the treatment of adults with polycythemia
vera (PV). This report aims to analyze the ethnic sensitivity of Ropeg for the treatment of PV …

Ropeginterferon alfa-2b shows anti-polycythaemia vera activity without causing clinically significant anaemia

K Kirito, A Qin, S Suo, R Fu, D Wu, T Sato… - BJC Reports, 2024 - nature.com
Anaemia could develop in polycythemia vera (PV) due to phlebotomy-caused iron-
deficiency and cytotoxic effect of cytoreductive therapy. Ropeginterferon alfa-2b treatment …

Cost–effectiveness of ropeginterferon alfa-2b-njft for the treatment of polycythemia vera

AT Gerds, C Castro, F Snopek… - Journal of …, 2023 - becarispublishing.com
Aim: Patients with polycythemia vera (PV), a rare and chronic blood cancer, are at a higher
risk for thromboembolic events, progression to myelofibrosis, and leukemic transformation …

Interferons in the treatment of myeloproliferative neoplasms

P Vachhani, J Mascarenhas, P Bose… - Therapeutic …, 2024 - journals.sagepub.com
Interferons are cytokines with immunomodulatory properties and disease-modifying effects
that have been used to treat myeloproliferative neoplasms (MPNs) for more than 35 years …