Primary prevention trials have shifted their focus to the earliest stages of Alzheimer's disease
(AD). Autopsy data indicates that the neuromodulatory subcortical systems'(NSS) nuclei are …

Animal and human imaging research reported that the presence of cortical Alzheimer's
Disease's (AD) neuropathology, beta-amyloid and neurofibrillary tau, is associated with …

Background: The locus coeruleus (LC) is a nucleus in the human brainstem with a variety of
noradrenaline-driven functions involved in cognition, emotions, and perception. Dementia …

Sustained attention, the ability to focus on an activity or stimulus over time, is significantly
impaired in many psychiatric disorders, and there remains a major unmet need in treating …

Background: The locus coeruleus (LC) is one of the earliest brain regions to accumulate
hyperphosphorylated tau, but a lack of animal models that recapitulate this pathology has …

Studies have shown that functional abnormalities in the locus coeruleus (LC) are strongly
associated with depressive symptoms, but the pattern of LC functional connectivity in …

Background Mental syndromes such as anxiety and depression are common comorbidities
in patients with chronic insomnia disorder (CID). The locus coeruleus noradrenergic (LC …

The locus coeruleus (LC) is an important noradrenergic nucleus that has recently attracted a
lot of attention because of its emerging role in cognitive and psychiatric disorders. Although …

Introduction The brainstem locus coeruleus (LC) influences a broad range of brain
processes, including cognition. The so-called LC contrast is an accepted marker of the …

Introduction The neural mechanisms underlying neurodegenerative disorders in the elderly
remain elusive, despite extensive neuroimaging research in recent decades. Amnestic type …