Backgrounds: Psoraleae Fructus (PF)-induced hepatotoxicity has been reported in clinical
and animal experiments. However, the hepatotoxic constituents and mechanisms underlying …

Mesenteric metastases in small intestinal neuroendocrine tumors (SI-NETs) are associated
with mesenteric fibrosis (MF) in a proportion of patients. MF can induce severe abdominal …

Purpose Tumor necrosis factor-α (TNF-α) has been shown to exert as a pathogenic factor in
cardiac fibrosis and heart failure which were associated with the up-regulation of …

Recent findings suggest that extracellular heat shock protein 90α (eHSP90α) promotes
pulmonary fibrosis, but the underlying mechanisms are not well understood. Aging …

Mitochondrial dysfunction, a feature of heart failure, leads to a progressive decline in
bioenergetic reserve capacity, consisting in a shift of energy production from mitochondrial …

Objectives Periodontitis is closely associated with kidney disease and reactive oxygen
species (ROS) involvement. Mitochondria are the primary source of both endogenous ROS …

Mitochondria are the energy source for basal cell functions as well as for tissue repair and
regeneration. Excessive accumulation of reactive oxygen species (ROS) generated by bone …

Symptoms of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) are common in
rheumatic diseases, but no studies report the frequency of these in early systemic sclerosis …

Peritoneal dialysis (PD) is a widely accepted renal replacement therapy for patients with end-
stage renal disease (ESRD). Morphological and functional changes occur in the peritoneal …

TOLLIP (Toll-interacting protein) is an intracellular adaptor protein with diverse actions
throughout the body. In a context-and cell type–specific manner, TOLLIP can function as an …