Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease

V Panwar, A Singh, M Bhatt, RK Tonk… - Signal transduction and …, 2023 - nature.com
The mammalian target of rapamycin (mTOR) is a protein kinase that controls cellular
metabolism, catabolism, immune responses, autophagy, survival, proliferation, and …

The long and short non-coding RNAs modulating EZH2 signaling in cancer

S Mirzaei, MH Gholami, K Hushmandi… - Journal of hematology & …, 2022 - Springer
Non-coding RNAs (ncRNAs) are a large family of RNA molecules with no capability in
encoding proteins. However, they participate in developmental and biological processes …

The multidimensional role of the Wnt/β‐catenin signaling pathway in human malignancies

IS Hiremath, A Goel, S Warrier… - Journal of Cellular …, 2022 - Wiley Online Library
Several signaling pathways have been identified as important for developmental processes.
One of such important cascades is the Wnt/β‐catenin signaling pathway, which can regulate …

The pleiotropic role of transcription factor STAT3 in oncogenesis and its targeting through natural products for cancer prevention and therapy

M Garg, MK Shanmugam, V Bhardwaj… - Medicinal research …, 2021 - Wiley Online Library
Signal transducer and activator of transcription 3 (STAT3) is one of the crucial transcription
factors, responsible for regulating cellular proliferation, cellular differentiation, migration …

Rationalizing the therapeutic potential of apigenin against cancer

SA Ahmed, D Parama, E Daimari, S Girisa, K Banik… - Life sciences, 2021 - Elsevier
Background Despite the remarkable advances made in the diagnosis and treatment of
cancer during the past couple of decades, it remains the second largest cause of mortality in …

Metal nanoparticles in cancer: from synthesis and metabolism to cellular interactions

HS Tuli, R Joshi, G Kaur, VK Garg, K Sak… - Journal of Nanostructure …, 2023 - Springer
Nanotechnology has encouraged new and amended materials (metal nanoparticles) for
therapeutic applications with specific prominence in healthcare. Metal nanoparticles (NPs) …

Drug repurposing for cancer therapy

Y Xia, M Sun, H Huang, WL Jin - Signal Transduction and Targeted …, 2024 - nature.com
Cancer, a complex and multifactorial disease, presents a significant challenge to global
health. Despite significant advances in surgical, radiotherapeutic and immunological …

The role of microRNA-338-3p in cancer: growth, invasion, chemoresistance, and mediators

S Mirzaei, A Zarrabi, SE Asnaf, F Hashemi, A Zabolian… - Life sciences, 2021 - Elsevier
Cancer still remains as one of the leading causes of death worldwide. Metastasis and
proliferation are abnormally increased in cancer cells that subsequently, mediate resistance …

Apoptotic mechanisms of quercetin in liver cancer: recent trends and advancements

G Sethi, P Rath, A Chauhan, A Ranjan, R Choudhary… - Pharmaceutics, 2023 - mdpi.com
Due to rising incidence rates of liver cancer and worries about the toxicity of current
chemotherapeutic medicines, the hunt for further alternative methods to treat this malignancy …

Sensing the scent of death: modulation of microRNAs by curcumin in gastrointestinal cancers

M Ashrafizadeh, A Zarrabi, M Hashemipour… - Pharmacological …, 2020 - Elsevier
Gastrointestinal (GI) cancers with a high incidence rate and adverse complications are
related to severe morbidity and mortality around the world. MicroRNAs (miRs) are potential …