The possible link between hIAPP accumulation and β-cell death in diabetic patients has
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …

The finding of islet inflammation in type 2 diabetes (T2D) and its involvement in β cell
dysfunction has further highlighted the significance of inflammation in metabolic diseases …

Background Protein aggregation correlates with the development of several debilitating
human disorders of growing incidence, such as Alzheimer's and Parkinson's diseases. On …

The hormone islet amyloid polypeptide (IAPP, or amylin) plays a role in glucose
homeostasis but aggregates to form islet amyloid in type‐2 diabetes. Islet amyloid formation …

This tutorial review presents descriptions of two amyloidogenic proteins, amyloid-β (Aβ)
peptides and islet amyloid polypeptide (IAPP), whose misfolding propensities are implicated …

The 37-residue amylin peptide, also known as islet amyloid polypeptide, forms fibrils that are
the main peptide or protein component of amyloid that develops in the pancreas of type 2 …

Human islet amyloid polypeptide (IAPP or amylin) is a 37‐residue hormone found as fibrillar
deposits in pancreatic extracts of nearly all type II diabetics. Although the cellular toxicity of …

1. Introduction 22. What is the significance of the shared structural properties of disease-
associated protein fibrils? 32.1 Mechanism of amyloid fibril formation in vitro 62.1. 1 In vitro …

Islet amyloid polypeptide (IAPP) is a 37-residue hormone that forms cytotoxic amyloid fibers
in the endocrine pancreas of patients with type II diabetes (NIDDM). A potential origin for …

Islet amyloid polypeptide (IAPP) forms cytotoxic oligomers and amyloid fibrils in islets in type
2 diabetes (T2DM). The causal factors for amyloid formation are largely unknown …