Incomplete response to Anti-VEGF therapy in neovascular AMD: Exploring disease mechanisms and therapeutic opportunities

PS Mettu, MJ Allingham, SW Cousins - Progress in retinal and eye …, 2021 - Elsevier
Intravitreal anti-vascular endothelial growth factor (VEGF) drugs have revolutionized the
treatment of neovascular age-related macular degeneration (NVAMD). However, many …

Molecular mechanism of VEGF and its role in pathological angiogenesis

A Ahmad, MI Nawaz - Journal of Cellular Biochemistry, 2022 - Wiley Online Library
Over the last seven decades, a significant scientific contribution took place in the delineation
of the implications of vascular endothelial‐derived growth factor (VEGF) in the processes of …

[HTML][HTML] Mechanisms of blue light-induced eye hazard and protective measures: a review

X Ouyang, J Yang, Z Hong, Y Wu, Y Xie… - Biomedicine & …, 2020 - Elsevier
The risk of blue light exposure to human health has attracted increased research attention.
Blue light, with relatively high energy, can cause irreversible photochemical damage to eye …

VEGF-targeting drugs for the treatment of retinal neovascularization in diabetic retinopathy

A Arrigo, E Aragona, F Bandello - Annals of medicine, 2022 - Taylor & Francis
Diabetic retinopathy (DR) is the most common microangiopathic complication of diabetes
mellitus, representing a major cause of visual impairment in developed countries …

[HTML][HTML] Microneedles for advanced ocular drug delivery

K Glover, D Mishra, S Gade, LK Vora, Y Wu… - Advanced drug delivery …, 2023 - Elsevier
In the field of ocular drug delivery, topical delivery remains the most common treatment
option for managing anterior segment diseases, while intraocular injections are the current …

[HTML][HTML] Anti-VEGF-resistant retinal diseases: a review of the latest treatment options

JO Wallsh, RP Gallemore - Cells, 2021 - mdpi.com
Anti-vascular endothelial growth factor (anti-VEGF) therapy currently plays a central role in
the treatment of numerous retinal diseases, most notably exudative age-related macular …

Risk factors and biomarkers of age-related macular degeneration

NG Lambert, H ElShelmani, MK Singh… - Progress in retinal and …, 2016 - Elsevier
A biomarker can be a substance or structure measured in body parts, fluids or products that
can affect or predict disease incidence. As age-related macular degeneration (AMD) is the …

Vitamin C in disease prevention and cure: an overview

S Chambial, S Dwivedi, KK Shukla, PJ John… - Indian journal of clinical …, 2013 - Springer
The recognition of vitamin C is associated with a history of an unrelenting search for the
cause of the ancient haemorrhagic disease scurvy. Isolated in 1928, vitamin C is essential …

Corneal neovascularization

MP Nicholas, N Mysore - Experimental eye research, 2021 - Elsevier
The optical clarity of the cornea is essential for maintaining good visual acuity. Corneal
neovascularization, which is a major cause of vision loss worldwide, leads to corneal …

Diabetic retinopathy: vascular and inflammatory disease

F Semeraro, A Cancarini, R dell'Omo… - Journal of diabetes …, 2015 - Wiley Online Library
Diabetic retinopathy (DR) is the leading cause of visual impairment in the working‐age
population of the Western world. The pathogenesis of DR is complex and several vascular …