Myocardial ischemia-reperfusion injury; Molecular mechanisms and prevention

Y Liu, L Li, Z Wang, J Zhang, Z Zhou - Microvascular Research, 2023 - Elsevier
Cardiovascular diseases are one of the leading causes of mortality in developed countries.
Among cardiovascular disorders, myocardial infarction remains a life-threatening problem …

Saponins in Chinese herbal medicine exerts protection in myocardial ischemia–reperfusion injury: Possible mechanism and target analysis

R Wang, M Wang, J Zhou, D Wu, J Ye… - Frontiers in …, 2021 - frontiersin.org
Myocardial ischemia is a high-risk disease among middle-aged and senior individuals. After
thrombolytic therapy, heart tissue can potentially suffer further damage, which is called …

Resveratrol protects ROS-induced cell death by activating AMPK in H9c2 cardiac muscle cells

JT Hwang, DY Kwon, OJ Park, MS Kim - Genes & nutrition, 2008 - Springer
Resveratrol, one of polyphenols derived from red wine, has been shown to protect against
cell death, possibly through the association with several signaling pathways. Currently …

Neurodegeneration in streptozotocin-induced diabetic rats is attenuated by treatment with resveratrol

YH Jing, KH Chen, PC Kuo, CC Pao, JK Chen - Neuroendocrinology, 2013 - karger.com
Aim: Diabetes mellitus-associated hyperglycemia and oxidative stress have been shown to
have detrimental effects on the brain and may lead to impairment of cognitive functions …

Nanoparticle-Mediated Dual Delivery of an Antioxidant and a Peptide against the L-Type Ca2+ Channel Enables Simultaneous Reduction of Cardiac Ischemia …

N Hardy, HM Viola, VPA Johnstone, TD Clemons… - Acs Nano, 2015 - ACS Publications
Increased reactive oxygen species (ROS) production and elevated intracellular Ca2+
following cardiac ischemia-reperfusion injury are key mediators of cell death and the …

Blueberry-enriched diet protects rat heart from ischemic damage

I Ahmet, E Spangler, B Shukitt-Hale, M Juhaszova… - PLoS …, 2009 - journals.plos.org
Objectives to assess the cardioprotective properties of a blueberry enriched diet (BD).
Background Reactive oxygen species (ROS) play a major role in ischemia-related …

Structural apelin analogues: mitochondrial ROS inhibition and cardiometabolic protection in myocardial ischaemia reperfusion injury

O Pisarenko, V Shulzhenko, I Studneva… - British Journal of …, 2015 - Wiley Online Library
Background and Purpose Mitochondria‐derived oxidative stress is believed to be crucially
involved in cardiac ischaemia reperfusion (I/R) injury, although currently no therapies exist …

Hyaluronic acid-dependent protection in H9C2 cardiomyocytes: A cell model of heart ischemia–reperfusion injury and treatment

CH Law, JM Li, HC Chou, YH Chen, HL Chan - Toxicology, 2013 - Elsevier
Hyaluronic acid (HA), a glycosaminoglycan with high molecular weight, has been reported
to promote cell proliferation and serves as an important extracellular matrix component. The …

Comparison of mechanisms involved in impaired vascular reactivity between high sucrose and high fat diets in rats

KL Sweazea, M Lekic, BR Walker - Nutrition & metabolism, 2010 - Springer
Background To determine the effects of high sucrose diets on vascular reactivity. We
hypothesized that similar to high fat diets (HFD), HSD feeding would lead to increased …

Establishing Salvia miltiorrhiza-Derived Exosome-like Nanoparticles and Elucidating Their Role in Angiogenesis

S Zhang, J Xia, Y Zhu, M Dong, J Wang - Molecules, 2024 - mdpi.com
Exosomes are multifunctional, cell-derived nanoscale membrane vesicles. Exosomes
derived from certain mammalian cells have been developed as angiogenesis promoters for …