Liquid–liquid phase separation (LLPS) has emerged in recent years as an important
physicochemical process for organizing diverse processes within cells via the formation of …

Liquid–liquid phase separation (LLPS) is a novel principle for interpreting precise
spatiotemporal coordination in living cells through biomolecular condensate (BMC) …

Metastatic dissemination is the leading cause of death in cancer patients, which is
particularly evident for high-risk sarcomas such as Ewing sarcoma, osteosarcoma, and …

Under cell stress, global protein synthesis is inhibited to preserve energy. One mechanism is
to sequester and silence mRNAs in ribonucleoprotein complexes known as stress granules …

The Y Box binding protein 1 (YB-1) is a member of the highly conserved Cold Shock Domain
protein family with multifunctional properties both in the cytoplasm and inside the nucleus …

Background Triple-negative breast cancer (TNBC) is associated with aggressiveness and a
poor prognosis. Besides surgery, radiotherapy serves as the major treatment modality for …

Outcomes for metastatic Ewing sarcoma and osteosarcoma are dismal and have not
changed for decades. Oxidative stress attenuates melanoma metastasis, and melanoma …

Osteosarcoma is an aggressive cancer in skeletal system with unknown molecular
mechanisms of etiology and pathogenesis, therefore it remains a challenge for current …

Identifying novel drug targets to overcome resistance to tyrosine kinase inhibitors (TKIs) and
eradicating leukemia stem/progenitor cells are required for the treatment of chronic …

In eukaryotic cells, biological activities are executed in distinct cellular compartments or
organelles. Canonical organelles with membrane‐bound structures are well understood …