Tobacco and nicotine use are associated with disease susceptibility and progression.
Health challenges associated with nicotine and smoking include developmental delays …

Chemical modifications to nucleic acids occur across the kingdoms of life and carry
important regulatory information. Reliable high-resolution mapping of these modifications is …

Mobility of transposable elements (TEs) frequently leads to insertional mutations in
functional DNA regions. In the potentially immortal germline, TEs are effectively suppressed …

The proper transfer of genetic information from DNA to RNA to protein is essential for cell-
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …

Skeletal muscle development and regeneration is governed by the combined action of Myf5,
MyoD, Mrf4 and MyoG, also known as the myogenic regulatory factors (MRFs). These …

Epigenetic dysregulation emerges as a critical hallmark and driving force of aging. Although
still an evolving field with much to explore, it has rapidly gained significance by providing …

Abstract Background The Fe (II)-and α-ketoglutarate-dependent AlkB family dioxygenases
are implicated in nucleotide demethylation. AlkB homolog1 (ALKBH1) is shown to …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and represents the
leading cause of cognitive impairment and dementia in older individuals throughout the …

Summary DNA N 6-methyldeoxyadenosine (6mA) modification was first discovered in
Bacterium coli in the 1950s. Over the next several decades, 6mA was recognized as a …

B cells play a pivotal role in the pathogenesis of autoimmune diseases. Although previous
studies have shown many genetic polymorphisms associated with B-cell activation in …