Antibiotic heteroresistance is a phenotype in which a bacterial isolate contains
subpopulations of cells that show a substantial reduction in antibiotic susceptibility …

Conventional proton pump inhibitors (PPIs) are used as a first-line therapy to treat acid-
related diseases worldwide. However, they have a number of limitations including slow …

Although susceptibility-guided therapy is frequently recommended for Helicobacter pylori
infection, the evidence available to date supporting this strategy is limited. The aim of the …

Introduction: Helicobacter pylori is a Gram-negative bacterium that causes chronic gastritis,
dyspepsia, peptic ulcers, and gastric cancer. Over half the world's population is infected with …

Resumen La Organización Mundial de la Salud estima que en 2050 la resistencia
bacteriana ocasionará 10 millones de muertes. Como parte del Plan de Acción Mundial …

Background Heteroresistance is a general term to describe diverse responses to specific
antibiotics that can occur due to infection with either multiple bacterial strains or …

Transition state theory teaches that chemically stable mimics of enzymatic transition states
will bind tightly to their cognate enzymes. Kinetic isotope effects combined with …

With the apparent stagnation in the antibiotic discovery and the propagation of multidrug
resistance, Helicobacter pylori associated gastric infections are hard to eradicate. In …

Background Antibiotic resistance is a well‐known factor of Helicobacter pylori eradication
failure. Heteroresistance indicates the coexistence of resistant and susceptible strains and …

Helicobacter pylori (H. pylori) is the most common chronic bacterial infection, affecting
approximately half of the world's population. H. pylori is a Class I carcinogen according to …