Sleep is implicated in cognitive functioning in young adults. With increasing age, there are
substantial changes to sleep quantity and quality, including changes to slow-wave sleep …

Dendritic spines are the major sites of synaptic transmission in the central nervous system.
Alterations in the strength of synaptic connections directly affect the neuronal …

Abstract Background Apolipoprotein E (apoE) is a major carrier of cholesterol and essential
for synaptic plasticity. In brain, it's expressed by many cells but highly expressed by the …

Traditional pharmacological treatments for depression have a delayed therapeutic onset,
ranging from several weeks to months, and there is a high percentage of individuals who …

Depression is a leading cause of disability worldwide and a major contributor to the burden
of suicide. A major limitation of classical antidepressants is that 2–4 weeks of continuous …

Background and Purpose Sleep deprivation compromises learning and memory in both
humans and animals, and can be reversed by administration of modafinil, a drug promoting …

Highlights•Restoring hippocampal cAMP levels prevents sleep deprivation-induced memory
deficits.•Blocking hippocampal PDE4A5 function prevents memory deficits caused by sleep …

In this narrative review article, we discuss the role of sleep deprivation (SD) in memory
processing in rodent models. Numerous studies have examined the effects of SD on …

It is well established that sleep deprivation after learning impairs hippocampal memory
processes and can cause amnesia. It is unknown, however, whether sleep deprivation leads …

Sleep and sleep loss have a profound impact on hippocampal function, leading to memory
impairments. Modifications in the strength of synaptic connections directly influences …