Tumor abnormality-oriented nanomedicine design

Q Zhou, J Xiang, N Qiu, Y Wang, Y Piao, S Shao… - Chemical …, 2023 - ACS Publications
Anticancer nanomedicines have been proven effective in mitigating the side effects of
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …

Autophagy inhibitors for cancer therapy: small molecules and nanomedicines

JL Chen, X Wu, D Yin, XH Jia, X Chen, ZY Gu… - Pharmacology & …, 2023 - Elsevier
Autophagy is a conserved process in which the cytosolic materials are degraded and
eventually recycled for cellular metabolism to maintain homeostasis. The dichotomous role …

Revealing the mutually enhanced mechanism of necroptosis and immunotherapy induced by defect engineering and piezoelectric effect

Y Du, J Yang, F He, X Zhao, J Zhou, P Zang… - Advanced …, 2024 - Wiley Online Library
Owing to low immunogenicity‐induced immune escape and short‐term circulating immune
responses, the efficiency of immunotherapy is unsatisfactory. Therefore, triggering …

Manganese-Based Immunostimulatory Metal–Organic Framework Activates the cGAS-STING Pathway for Cancer Metalloimmunotherapy

SJ Zheng, M Yang, JQ Luo, R Liu, J Song, Y Chen… - ACS …, 2023 - ACS Publications
Metal–organic frameworks (MOFs) show tremendous promise for drug delivery due to their
structural and functional versatility. However, MOFs are usually used as biologically inert …

Multifunctional 3D-printed scaffolds eradiate orthotopic osteosarcoma and promote osteogenesis via microwave thermo-chemotherapy combined with immunotherapy

L Ma, J Zhou, Q Wu, G Luo, M Zhao, G Zhong, Y Zheng… - Biomaterials, 2023 - Elsevier
Tumor recurrence and a lack of bone-tissue integration are two critical concerns in the
surgical treatment of osteosarcoma. Thus, an advanced multifunctional therapeutic platform …

Liquid nanoparticles for nanocatalytic cancer therapy

R Hu, X Chen, Z Li, G Zhao, L Ding, L Chen… - Advanced …, 2023 - Wiley Online Library
Nanotechnology is revolutionizing cancer therapy, and catalyzes the emerging of ion‐
involved cancer‐therapeutic modality, which unfortunately suffers from undesirable …

Disruption of Zinc Homeostasis by a Novel Platinum (IV)‐Terthiophene Complex for Antitumor Immunity

X Su, B Liu, WJ Wang, K Peng, BB Liang… - Angewandte …, 2023 - Wiley Online Library
Zinc homeostatic medicine is of great potential for cancer chemo‐immunotherapy; however,
there are few reports on antitumor compounds that can trigger Zn2+‐mediated immune …

Beyond drug delivery system: immunomodulatory layered double hydroxide nanoadjuvants take an essential step forward in cancer immunotherapy

C Zhu, J Jiang, Y Jia, ZP Xu… - Accounts of Materials …, 2023 - ACS Publications
Conspectus Layered double hydroxide (LDH) is an anionic two-dimensional plate-like
nanomaterial consisting of positively charged divalent and trivalent cation layers and anion …

cGAS-STING signaling in the tumor microenvironment

Z Liu, D Wang, J Zhang, P Xiang, Z Zeng, W Xiong… - Cancer Letters, 2023 - Elsevier
The cGAS-STING signaling is an important pathway involved in the regulation of tumor
microenvironment, which affects many cellular functions including immune activation. Its role …

Nanomedicine-mediated regulated cell death in cancer immunotherapy

Y Sun, T Lian, Q Huang, Y Chang, Y Li, X Guo… - Journal of Controlled …, 2023 - Elsevier
Immunotherapy has attracted widespread attention in cancer treatment and has achieved
considerable success in the clinical treatment of some tumors, but it has a low response rate …