Pharmacokinetic/pharmacodynamic (PK/PD) analysis has proved to be very useful to
establish rational dosage regimens of antimicrobial agents in human and veterinary …

Early initiation of effective antibiotic therapy is vitally important for saving the lives of critically
ill patients with sepsis or septic shock. The susceptibility of the infecting pathogen and the …

Methods: In this study, several simple methods to project a first-in-pediatric dose to initiate a
clinical trial were evaluated. These methods were as follows:(1) Weight-based pediatric …

There is a growing interest in the use of physiologically based pharmacokinetic (PBPK)
models as clinical pharmacology drug development tools. In PBPK modeling, not every …

This prospective study aimed to explore the determinants of meropenem trough
concentration (Ctrough) in patients with bacterial pneumonia and to investigate the …

Objective The objective of this study was to compare the predictive performances of a
glomerular filtration rate (GFR) model with a physiologically based pharmacokinetic (PBPK) …

Objectives The objective of this study was to develop a population pharmacokinetic model of
meropenem in a heterogeneous population of patients with a serious bacterial infection in …

We thank De Sutter, De Waele, and Vermeulen for their comments and interest regarding
our publication on the penetration of antibacterial agents into pulmonary epithelial lining …

We read the recent article by Drwiega and Rodvold on the penetration of antibacterial
agents into pulmonary epithelial lining fluid (ELF)[1] with great interest. We thank the authors …

The aim of this chapter is to report analytical and individual-based methods for antibiotic
dose selection that are based on tools from system and control theory. A brief system …