Due to their efficient recognition and lysis of malignant cells, natural killer (NK) cells are
considered as specialized immune cells that can be genetically modified to obtain capable …

Patients with high risk neuroblastoma have a poor prognosis and survivors are often left with
debilitating long term sequelae from treatment. Even after integration of anti-GD2 …

Glioblastoma multiforme (GBM) is the most common and aggressive form of primary brain
cancer, for which effective therapies are urgently needed. Chimeric antigen receptor (CAR) …

Diffuse intrinsic pontine glioma (DIPG) and other diffuse midline gliomas (DMGs) with
mutated histone H3 K27M (H3-K27M),,,–are aggressive and universally fatal pediatric brain …

The reprogramming of a patient's immune system through genetic modification of the T cell
compartment with chimeric antigen receptors (CARs) has led to durable remissions in …

We are experiencing a revolution in cancer. Advances in screening, targeted and immune
therapies, big data, computational methodologies, and significant new knowledge of cancer …

The overall efficacy of chimeric antigen receptor modified T cells (CARTs) remain limited in
solid tumors despite intensive studies that aim at targeting multiple antigens, enhancing …

B-cell maturation antigen (BCMA) is a promising therapeutic target for multiple myeloma
(MM), but expression is variable, and early reports of BCMA targeting chimeric antigen …

Glycosphingolipids (GSLs) exhibit a variety of functions in cellular differentiation and
interaction. Also, they are known to play a role as receptors in pathogen invasion. A less well …

Long-term antitumor efficacy of chimeric antigen receptor (CAR) T cells depends on their
functional persistence in vivo. T cells with stem-like properties show better persistence, but …