Maintaining optimal mitochondrial function is a feature of health. Mitophagy removes and
recycles damaged mitochondria and regulates the biogenesis of new, fully functional ones …

Mitochondria retain bacterial traits due to their endosymbiotic origin, but host cells do not
recognize them as foreign because the organelles are sequestered. However, the regulated …

Pulmonary fibrosis is a progressive and ultimately fatal lung disease, exhibiting the
excessive production of extracellular matrix and aberrant activation of fibroblast. While …

Tumor immunotherapy as a new tumor therapy has been intensively studied and reported.
However, the expected utilization and therapeutic effects have not been achieved due to the …

Acetaminophen (APAP) is an analgesic and antipyretic drug used worldwide, which is safe
at therapeutic doses. However, an overdose can induce liver injury and even liver failure …

To survive, all organisms need the ability to accurately recognize and neutralize pathogens.
As a result, many of the fundamental strategies that our innate immune system uses to fight …

Although microglial activation is induced by an increase in chemokines, the role of
mitophagy in this process remains unclear. This study aimed to elucidate the role of …

The theory that oxidative damage caused by mitochondrial free radicals leads to aging has
brought mitochondria into the forefront of aging research. Psychological stress that …

Macrophage STING-YAP Axis Controls Hepatic Steatosis by Promoting Autophagic
Degradation of Lipid Droplets Tao Yang1,2,#, Xiaoye Page 1 Macrophage STING-YAP Axis …

Micronuclei (MN) have been associated with the innate immune response. The abrupt
rupture of MN membranes results in the accumulation of cGAS, potentially activating STING …