Immune targets for therapeutic development in depression: towards precision medicine
Over the past two decades, compelling evidence has emerged indicating that immune
mechanisms can contribute to the pathogenesis of major depressive disorder (MDD) and …
mechanisms can contribute to the pathogenesis of major depressive disorder (MDD) and …
Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 clinical guidelines for the management of adults with major depressive disorder: section 3 …
SH Kennedy, RW Lam, RS McIntyre… - The Canadian …, 2016 - journals.sagepub.com
Background: The Canadian Network for Mood and Anxiety Treatments (CANMAT)
conducted a revision of the 2009 guidelines by updating the evidence and …
conducted a revision of the 2009 guidelines by updating the evidence and …
Treatment selection in depression
ZD Cohen, RJ DeRubeis - Annual Review of Clinical …, 2018 - annualreviews.org
Mental health researchers and clinicians have long sought answers to the question “What
works for whom?” The goal of precision medicine is to provide evidence-based answers to …
works for whom?” The goal of precision medicine is to provide evidence-based answers to …
Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders
Objectives: To provide guidance for the management of mood disorders, based on scientific
evidence supplemented by expert clinical consensus and formulate recommendations to …
evidence supplemented by expert clinical consensus and formulate recommendations to …
Cross-trial prediction of treatment outcome in depression: a machine learning approach
AM Chekroud, RJ Zotti, Z Shehzad… - The Lancet …, 2016 - thelancet.com
Background Antidepressant treatment efficacy is low, but might be improved by matching
patients to interventions. At present, clinicians have no empirically validated mechanisms to …
patients to interventions. At present, clinicians have no empirically validated mechanisms to …
Combining antidepressants vs antidepressant monotherapy for treatment of patients with acute depression: a systematic review and meta-analysis
J Henssler, D Alexander, G Schwarzer, T Bschor… - JAMA …, 2022 - jamanetwork.com
Importance Combining antidepressants is frequently done in the treatment of acute
depression, but studies have yielded conflicting results. Objective To conduct a systematic …
depression, but studies have yielded conflicting results. Objective To conduct a systematic …
Monoamine neurocircuitry in depression and strategies for new treatments
M Hamon, P Blier - Progress in Neuro-Psychopharmacology and …, 2013 - Elsevier
Extensive studies showed that monoaminergic neurotransmission that involves serotonin (5-
HT), norepinephrine (NE) and dopamine (DA) exerts major influence on brain circuits …
HT), norepinephrine (NE) and dopamine (DA) exerts major influence on brain circuits …
Rapid and longer-term antidepressant effects of repeated ketamine infusions in treatment-resistant major depression
JW Murrough, AM Perez, S Pillemer, J Stern… - Biological …, 2013 - Elsevier
Background Ketamine is reported to have rapid antidepressant effects; however, there is
limited understanding of the time-course of ketamine effects beyond a single infusion. A …
limited understanding of the time-course of ketamine effects beyond a single infusion. A …
World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of unipolar depressive disorders, part 1: update 2013 on the acute …
Objectives. This 2013 update of the practice guidelines for the biological treatment of
unipolar depressive disorders was developed by an international Task Force of the World …
unipolar depressive disorders was developed by an international Task Force of the World …
Treatment-resistant depression: definitions, review of the evidence, and algorithmic approach
RS McIntyre, MJ Filteau, L Martin, S Patry… - Journal of affective …, 2014 - Elsevier
Background Most adults with major depressive disorder (MDD) fail to achieve remission with
index pharmacological treatment. Moreover, at least half will not achieve and sustain …
index pharmacological treatment. Moreover, at least half will not achieve and sustain …