Contingent upon concentration, reactive oxygen species (ROS) influence cancer evolution
in apparently contradictory ways, either initiating/stimulating tumorigenesis and supporting …

The majority of breast cancers express the estrogen receptor (ERα) and agents targeting this
pathway represent the main treatment modality. Endocrine therapy has proven successful in …

Background Genome-wide association studies (GWAS) have identified> 200 loci associated
with breast cancer risk. The majority of candidate causal variants are in non-coding regions …

Epithelial-mesenchymal transitions (EMT) are physiological programs during which
polarized, immobile epithelial cells lose connection with their neighbours and are converted …

The transcription factor zinc finger E-box binding homeobox 1 (ZEB1) is a critical inducer of
epithelial mesenchymal transformation (EMT) and plays a robust role in tumor metastasis. It …

Epithelial-mesenchymal plasticity (EMP) reflects the capacity of cells to interconvert between
epithelial and mesenchymal phenotypes. In cancer, these dynamics ultimately contribute to …

Orofacial clefts, including cleft lip and palate (CL/P) and neural tube defects (NTDs) are
among the most common congenital anomalies, but knowledge of the genetic basis of these …

Epithelial-mesenchymal plasticity (EMP) refers to the ability of cells to dynamically
interconvert between epithelial (E) and mesenchymal (M) phenotypes, thus generating an …

Osteoporosis and periodontitis are two major chronic diseases of postmenopausal women.
The association between these two diseases are evident through systemic bone loss and …

Grainyhead-like (GRHL) factors are essential, highly conserved transcription factors (TFs)
that regulate processes common to both natural cellular behaviours during embryogenesis …