Overview of nanozymes with phosphatase-like activity

Y Wu, W Chen, C Wang, D Xing - Biosensors and Bioelectronics, 2023 - Elsevier
Nanomaterials with intrinsic enzyme activity, referred to as nanozymes, have attracted
substantial attention in recent years. Among them, phosphatase-mimicking nanozymes have …

Mitochondrial disruption Nanosystem simultaneously depressed programmed death Ligand-1 and transforming growth Factor-β to overcome photodynamic …

X Jiang, L Yi, C Li, H Wang, W Xiong, Y Li, Z Zhou… - ACS …, 2024 - ACS Publications
Currently, limited photosensitizers possess the capacity to reverse tumor hypoxia and
reduce programmed death ligand-1 (PD-L1) and transforming growth factor-β (TGF-β) …

A tumor cell exosome-mimicking multifunctional nanozyme for targeted breast cancer radiotherapy

G Chen, D Jiang, S Ding, C Huang, D Zhu, H Jiang - Nanoscale, 2023 - pubs.rsc.org
Radiotherapy (RT) has been extensively used for the treatment of breast cancer. However,
the efficacy of RT is reduced by the high content of reducing species within cells (such as …

Synergistic action of cavity and catalytic sites in etched Pd–Cu2O octahedra to augment the peroxidase-like activity of Cu2O nanoparticles for the colorimetric …

X Kang, G Cao, J Wang, J Wang, X Zhu, M Fu… - Biosensors and …, 2024 - Elsevier
Despite the widespread use of nanozyme-based colorimetric assays in biosensing,
challenges such as limited catalytic efficiency, inadequate sensitivity to analytes, and …

Enzyme‐Responsive Branched Glycopolymer‐Based Nanoassembly for Co‐Delivery of Paclitaxel and Akt Inhibitor toward Synergistic Therapy of Gastric Cancer

X Song, H Cai, Z Shi, Z Li, X Zheng, K Yang… - Advanced …, 2024 - Wiley Online Library
Combined chemotherapy and targeted therapy holds immense potential in the management
of advanced gastric cancer (GC). GC tissues exhibit an elevated expression level of protein …

Mineral Phase Reconfiguration Enables the High Enzyme-like Activity of Vermiculite for Antibacterial Application

L Tian, Y Qian, H Wang, G Zhao, A Tang, H Yang - Nano Letters, 2023 - ACS Publications
Phyllosilicates-based nanomaterials, particularly iron-rich vermiculite (VMT), have wide
applications in biomedicine. However, the lack of effective methods to activate the functional …

Targeting PI3K/AKT/mTOR Signaling to Overcome Drug Resistance in Cancer

M Tufail, WD Wan, C Jiang, N Li - Chemico-Biological Interactions, 2024 - Elsevier
This review comprehensively explores the challenge of drug resistance in cancer by
focusing on the pivotal PI3K/AKT/mTOR pathway, elucidating its role in oncogenesis and …

Robinin inhibits pancreatic cancer cell proliferation, EMT and inflammation via regulating TLR2-PI3k-AKT signaling pathway

W Zhang, W Liu, X Hu - Cancer Cell International, 2023 - Springer
Purpose To investigate the anti-tumor effect of Robinin (Toll-like receptor 2 inhibitor) in
pancreatic cancer cells via regulating tumor microenvironment. Methods The effects of …

Mn-CaCO3-based nanosystem for augmented sonodynamic-chemodynamic immunotherapy via PI3K/Akt signaling pathway

M Sha, H Li, Y Liu, C Tang, X Bai, Y Wang… - Chemical Engineering …, 2024 - Elsevier
Cancer immunotherapy has improved the survival rate of patients with malignant tumors.
However, the response of solid tumors to immunotherapy is quite limited. Here, we report a …

[HTML][HTML] Nanoparticles (NPs)-mediated targeted regulation of redox homeostasis for effective cancer therapy

Z Zhao, Y Cao, R Xu, J Fang, Y Zhang, X Xu… - Smart Materials in …, 2024 - Elsevier
Although characterized by high reactive oxygen species (ROS) generation, cancer cells
maintain redox homeostasis to avoid severe damage (eg, DNA, protein, and plasma …