[HTML][HTML] NAFLD and cardiovascular diseases: a clinical review

P Kasper, A Martin, S Lang, F Kuetting… - Clinical research in …, 2021 - Springer
Non-alcoholic fatty liver DISEASE (NAFLD) is the most common chronic liver disease in
Western countries and affects approximately 25% of the adult population. Since NAFLD is …

The translational neuroscience of sleep: a contextual framework

MA Grandner, FX Fernandez - Science, 2021 - science.org
Sleep is entwined across many physiologic processes in the brain and periphery, thereby
exerting tremendous influence on our well-being. Yet sleep exists in a social-environmental …

[PDF][PDF] Sleep loss can cause death through accumulation of reactive oxygen species in the gut

A Vaccaro, YK Dor, K Nambara, EA Pollina, C Lin… - Cell, 2020 - cell.com
The view that sleep is essential for survival is supported by the ubiquity of this behavior, the
apparent existence of sleep-like states in the earliest animals, and the fact that severe sleep …

Lean NAFLD: a distinct entity shaped by differential metabolic adaptation

F Chen, S Esmaili, GB Rogers, E Bugianesi, S Petta… - Hepatology, 2020 - journals.lww.com
Conclusions This study demonstrates that E. multilocularis can induce T‐cell exhaustion
through inhibitory receptor TIGIT, and that blocking this checkpoint may reverse the …

Lifestyle factors and high-risk atherosclerosis: Pathways and mechanisms beyond traditional risk factors

K Lechner, C von Schacky… - European journal of …, 2020 - journals.sagepub.com
Despite major efforts to reduce atherosclerotic cardiovascular disease (ASCVD) burden with
conventional risk factor control, significant residual risk remains. Recent evidence on non …

Metabolically healthy versus metabolically unhealthy obesity

C Iacobini, G Pugliese, CB Fantauzzi, M Federici… - Metabolism, 2019 - Elsevier
Obesity-related disease complications reduce life quality and expectancy and increase
health-care costs. Some studies have suggested that obesity not always entails metabolic …

Pharmacotherapy of obesity: available medications and drugs under investigation

E Pilitsi, OM Farr, SA Polyzos, N Perakakis… - Metabolism, 2019 - Elsevier
Obesity is a chronic disease with a continuously rising prevalence that currently affects more
than half a billion people worldwide. Energy balance and appetite are highly regulated via …

[HTML][HTML] Effects of sleep manipulation on markers of insulin sensitivity: A systematic review and meta-analysis of randomized controlled trials

N Sondrup, AD Termannsen, JN Eriksen… - Sleep Medicine …, 2022 - Elsevier
Poor sleep habits are associated with increased risk of developing type 2 diabetes. In this
review and meta-analysis, we aimed to investigate the effects of sleep manipulation on …

Associations of short sleep duration with appetite‐regulating hormones and adipokines: A systematic review and meta‐analysis

J Lin, Y Jiang, G Wang, M Meng, Q Zhu, H Mei… - Obesity …, 2020 - Wiley Online Library
In the current study, a systematic review and meta‐analysis were conducted to summarize
and assess whether short sleep duration is associated with appetite‐regulating hormones …

[HTML][HTML] Sleep fragmentation increases blood pressure and is associated with alterations in the gut microbiome and fecal metabolome in rats

KA Maki, LA Burke, MW Calik… - Physiological …, 2020 - journals.physiology.org
The gut microbiota, via the production of metabolites entering the circulation, plays a role in
blood pressure regulation. Blood pressure is also affected by the characteristics of sleep. To …