First glimpses of the neurobiology of autism spectrum disorder

SJ Sanders - Current opinion in genetics & development, 2015 - Elsevier
Rapid progress in identifying the genes underlying autism spectrum disorder (ASD) has
provided the substrate for a first wave of analyses into the underlying neurobiology. This …

Humans as superorganisms: How microbes, viruses, imprinted genes, and other selfish entities shape our behavior

P Kramer, P Bressan - Perspectives on Psychological …, 2015 - journals.sagepub.com
Psychologists and psychiatrists tend to be little aware that (a) microbes in our brains and
guts are capable of altering our behavior;(b) viral DNA that was incorporated into our DNA …

Schizophrenia as a disorder of molecular pathways

S Horváth, K Mirnics - Biological psychiatry, 2015 - Elsevier
Over the last decade, transcriptome studies of postmortem tissue from subjects with
schizophrenia revealed that synaptic, mitochondrial, immune system, gamma-aminobutyric …

[PDF][PDF] Varying intolerance of gene pathways to mutational classes explain genetic convergence across neuropsychiatric disorders

S Shohat, E Ben-David, S Shifman - Cell reports, 2017 - cell.com
Genetic susceptibility to intellectual disability (ID), autism spectrum disorder (ASD), and
schizophrenia (SCZ) often arises from mutations in the same genes, suggesting that they …

[HTML][HTML] De novo mutations (DNMs) in autism spectrum disorder (ASD): Pathway and network analysis

A Alonso-Gonzalez, C Rodriguez-Fontenla… - Frontiers in …, 2018 - frontiersin.org
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder (NDD) defined by
impairments in social communication and social interactions, accompanied by repetitive …

Network-assisted analysis to prioritize GWAS results: principles, methods and perspectives

P Jia, Z Zhao - Human genetics, 2014 - Springer
Genome-wide association studies (GWAS) have rapidly become a powerful tool in genetic
studies of complex diseases and traits. Traditionally, single marker-based tests have been …

[HTML][HTML] De novo mutations from whole exome sequencing in neurodevelopmental and psychiatric disorders: from discovery to application

W Wang, R Corominas, GN Lin - Frontiers in genetics, 2019 - frontiersin.org
Neurodevelopmental and psychiatric disorders are a highly disabling and heterogeneous
group of developmental and mental disorders, resulting from complex interactions of genetic …

Network analysis of GWAS data

MDM Leiserson, JV Eldridge, S Ramachandran… - Current opinion in …, 2013 - Elsevier
Genome-wide association studies (GWAS) identify genetic variants that distinguish a control
population from a population with a specific trait. Two challenges in GWAS are:(1) …

The pattern of cortical dysfunction in a mouse model of a schizophrenia-related microdeletion

K Fénelon, B Xu, CS Lai, J Mukai, S Markx… - Journal of …, 2013 - Soc Neuroscience
We used a mouse model of the schizophrenia-predisposing 22q11. 2 microdeletion to
evaluate how this genetic lesion affects cortical neural circuits at the synaptic, cellular, and …

Kinesin Kif3b mutation reduces NMDAR subunit NR2A trafficking and causes schizophrenia‐like phenotypes in mice

AH Alsabban, M Morikawa, Y Tanaka, Y Takei… - The EMBO …, 2020 - embopress.org
The transport of N‐methyl‐d‐aspartate receptors (NMDAR s) is crucial for neuronal plasticity
and synapse formation. Here, we show that KIF 3B, a member of the kinesin superfamily …