First glimpses of the neurobiology of autism spectrum disorder
SJ Sanders - Current opinion in genetics & development, 2015 - Elsevier
Rapid progress in identifying the genes underlying autism spectrum disorder (ASD) has
provided the substrate for a first wave of analyses into the underlying neurobiology. This …
provided the substrate for a first wave of analyses into the underlying neurobiology. This …
Humans as superorganisms: How microbes, viruses, imprinted genes, and other selfish entities shape our behavior
Psychologists and psychiatrists tend to be little aware that (a) microbes in our brains and
guts are capable of altering our behavior;(b) viral DNA that was incorporated into our DNA …
guts are capable of altering our behavior;(b) viral DNA that was incorporated into our DNA …
Schizophrenia as a disorder of molecular pathways
Over the last decade, transcriptome studies of postmortem tissue from subjects with
schizophrenia revealed that synaptic, mitochondrial, immune system, gamma-aminobutyric …
schizophrenia revealed that synaptic, mitochondrial, immune system, gamma-aminobutyric …
[PDF][PDF] Varying intolerance of gene pathways to mutational classes explain genetic convergence across neuropsychiatric disorders
Genetic susceptibility to intellectual disability (ID), autism spectrum disorder (ASD), and
schizophrenia (SCZ) often arises from mutations in the same genes, suggesting that they …
schizophrenia (SCZ) often arises from mutations in the same genes, suggesting that they …
[HTML][HTML] De novo mutations (DNMs) in autism spectrum disorder (ASD): Pathway and network analysis
A Alonso-Gonzalez, C Rodriguez-Fontenla… - Frontiers in …, 2018 - frontiersin.org
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder (NDD) defined by
impairments in social communication and social interactions, accompanied by repetitive …
impairments in social communication and social interactions, accompanied by repetitive …
Network-assisted analysis to prioritize GWAS results: principles, methods and perspectives
Genome-wide association studies (GWAS) have rapidly become a powerful tool in genetic
studies of complex diseases and traits. Traditionally, single marker-based tests have been …
studies of complex diseases and traits. Traditionally, single marker-based tests have been …
[HTML][HTML] De novo mutations from whole exome sequencing in neurodevelopmental and psychiatric disorders: from discovery to application
Neurodevelopmental and psychiatric disorders are a highly disabling and heterogeneous
group of developmental and mental disorders, resulting from complex interactions of genetic …
group of developmental and mental disorders, resulting from complex interactions of genetic …
Network analysis of GWAS data
MDM Leiserson, JV Eldridge, S Ramachandran… - Current opinion in …, 2013 - Elsevier
Genome-wide association studies (GWAS) identify genetic variants that distinguish a control
population from a population with a specific trait. Two challenges in GWAS are:(1) …
population from a population with a specific trait. Two challenges in GWAS are:(1) …
The pattern of cortical dysfunction in a mouse model of a schizophrenia-related microdeletion
K Fénelon, B Xu, CS Lai, J Mukai, S Markx… - Journal of …, 2013 - Soc Neuroscience
We used a mouse model of the schizophrenia-predisposing 22q11. 2 microdeletion to
evaluate how this genetic lesion affects cortical neural circuits at the synaptic, cellular, and …
evaluate how this genetic lesion affects cortical neural circuits at the synaptic, cellular, and …
Kinesin Kif3b mutation reduces NMDAR subunit NR2A trafficking and causes schizophrenia‐like phenotypes in mice
AH Alsabban, M Morikawa, Y Tanaka, Y Takei… - The EMBO …, 2020 - embopress.org
The transport of N‐methyl‐d‐aspartate receptors (NMDAR s) is crucial for neuronal plasticity
and synapse formation. Here, we show that KIF 3B, a member of the kinesin superfamily …
and synapse formation. Here, we show that KIF 3B, a member of the kinesin superfamily …