Objective Mental illness is the leading cause of disability in the USA, but boundaries
between different mental illnesses are notoriously difficult to define. Electronic medical …

Background Visuospatial working memory (vsWM), which is commonly impaired in
schizophrenia, involves information processing across the primary visual cortex, association …

Neurodegenerative phenotypes reflect complex, time-dependent molecular processes
whose elucidation may reveal neuronal class-specific therapeutic targets. The current focus …

Schizophrenia (SZ) and autism spectrum disorder (ASD) share deficits in emotion
processing. In order to identify convergent and divergent mechanisms, we investigated facial …

Autism spectrum disorder is a neurodevelopmental disorder present in 1% of the population,
characterized by impairments in reciprocal social interaction, communication deficits and …

We propose an improved mixed model of schizophrenia risk in which abnormal epigenetic
states with large effects are superimposed on a polygenic liability to schizophrenia. This …

In the last two decades, the term synaptopathy has been largely used to underline the
concept that impairments of synaptic structure and function are the major determinant of …

Neuronal axons are guided to their target during the development of the brain. Axon
guidance allows the formation of intricate neural circuits that control the function of the brain …

Background Individuals with schizophrenia spectrum disorders (SSD) often demonstrate
cognitive impairments, associated with poor functional outcomes. While neurobiological …

Detecting relative rather than absolute changes in extracellular signals enables cells to
make decisions in constantly fluctuating environments. It is currently not well understood …