The proteome of BLOC-1 genetic defects identifies the Arp2/3 actin polymerization complex to function downstream of the schizophrenia susceptibility factor dysbindin …
A Gokhale, C Hartwig, AH Freeman, R Das… - Journal of …, 2016 - Soc Neuroscience
Proteome modifications downstream of monogenic or polygenic disorders have the potential
to uncover novel molecular mechanisms participating in pathogenesis and/or extragenic …
to uncover novel molecular mechanisms participating in pathogenesis and/or extragenic …
MeCP2 dysfunction in rett syndrome and neuropsychiatric disorders
EWM Chin, ELK Goh - Psychiatric Disorders: Methods and Protocols, 2019 - Springer
Elucidating the functions of a particular gene is paramount to the understanding of how its
dysfunction contributes to disease. This is especially important when the gene is implicated …
dysfunction contributes to disease. This is especially important when the gene is implicated …
[HTML][HTML] Polygenic risk for autism spectrum disorder affects left amygdala activity and negative emotion in schizophrenia
Although the diagnoses based on phenomenology have many practical advantages,
accumulating evidence shows that schizophrenia and autism spectrum disorder (ASD) …
accumulating evidence shows that schizophrenia and autism spectrum disorder (ASD) …
[HTML][HTML] Cell migration in schizophrenia: Patient-derived cells do not regulate motility in response to extracellular matrix
JY Tee, R Sutharsan, Y Fan, A Mackay-Sim - Molecular and Cellular …, 2017 - Elsevier
Schizophrenia is a highly heritable psychiatric disorder linked to a large number of risk
genes. The function of these genes in disease etiology is not fully understood but pathway …
genes. The function of these genes in disease etiology is not fully understood but pathway …
Spatial genome exploration in the context of cognitive and neurological disease
P Rajarajan, T Borrman, W Liao, S Espeso-Gil… - Current opinion in …, 2019 - Elsevier
Highlights•Review of Hi-C genome-scale chromosome conformation ('3D Genome')
mappings in brain.•Discussion of developmental 3DG reorganization in differentiating …
mappings in brain.•Discussion of developmental 3DG reorganization in differentiating …
[HTML][HTML] System-based proteomic and metabonomic analysis of the Df (16) A+/− mouse identifies potential miR-185 targets and molecular pathway alterations
Abstract Deletions on chromosome 22q11. 2 are a strong genetic risk factor for development
of schizophrenia and cognitive dysfunction. We employed shotgun liquid chromatography …
of schizophrenia and cognitive dysfunction. We employed shotgun liquid chromatography …
[HTML][HTML] Chromatin remodeling dysfunction extends the etiological spectrum of schizophrenia: a case report
A Poisson, N Chatron, A Labalme, P Fourneret… - BMC Medical …, 2020 - Springer
Background The role of deleterious copy number variations in schizophrenia is well
established while data regarding pathogenic variations remain scarce. We report for the first …
established while data regarding pathogenic variations remain scarce. We report for the first …
A modular framework for gene set analysis integrating multilevel omics data
Modern high-throughput methods allow the investigation of biological functions across
multiple 'omics' levels. Levels include mRNA and protein expression profiling as well as …
multiple 'omics' levels. Levels include mRNA and protein expression profiling as well as …
[HTML][HTML] Association Between FoxO1, A2M, and TGF-β1, Environmental Factors, and Major Depressive Disorder
M Zhao, L Chen, Z Qiao, J Zhou, T Zhang… - Frontiers in …, 2020 - frontiersin.org
Introduction Investigations of gene-environment (G× E) interactions in major depressive
disorder (MDD) have been limited to hypothesis testing of candidate genes while poly-gene …
disorder (MDD) have been limited to hypothesis testing of candidate genes while poly-gene …
Coexpression enrichment analysis at the single-cell level reveals convergent defects in neural progenitor cells and their cell-type transitions in neurodevelopmental …
A large number of genes have been implicated in neurodevelopmental disorders (NDDs),
but their contributions to NDD pathology are difficult to decipher without understanding their …
but their contributions to NDD pathology are difficult to decipher without understanding their …