The exceptional vulnerability of humans to Alzheimer's disease

LC Walker, M Jucker - Trends in molecular medicine, 2017 - cell.com
Like many humans, non-human primates deposit copious misfolded Aβ protein in the brain
as they age. Nevertheless, the complete behavioral and pathologic phenotype of …

[图书][B] The bioarchaeology of metabolic bone disease

MB Brickley, R Ives, S Mays - 2020 - books.google.com
The Bioarchaeology of Metabolic Bone Disease, Second Edition is a comprehensive source
dedicated to better understanding this group of conditions that have significant …

Translational animal models for Alzheimer's disease: an Alzheimer's association business consortium think tank

MP Vitek, JA Araujo, M Fossel… - … Research & Clinical …, 2020 - Wiley Online Library
Over 5 million Americans and 50 million individuals worldwide are living with Alzheimer's
disease (AD). The progressive dementia associated with AD currently has no cure. Although …

[HTML][HTML] Age and sex-associated variation in the multi-site microbiome of an entire social group of free-ranging rhesus macaques

MC Janiak, MJ Montague, CI Villamil, MK Stock… - Microbiome, 2021 - Springer
Background An individual's microbiome changes over the course of its lifetime, especially
during infancy, and again in old age. Confounding factors such as diet and healthcare make …

[HTML][HTML] Mammalian Models in Alzheimer's Research: An Update

H Sharma, KA Chang, J Hulme, SSA An - Cells, 2023 - mdpi.com
A form of dementia distinct from healthy cognitive aging, Alzheimer's disease (AD) is a
complex multi-stage disease that currently afflicts over 50 million people worldwide …

Alzheimer's disease: A clinical perspective and future nonhuman primate research opportunities

RU Haque, AI Levey - … of the national Academy of Sciences, 2019 - National Acad Sciences
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is the sixth
leading cause of death and the most common cause of dementia worldwide. Over the last …

Glial cell morphological and density changes through the lifespan of rhesus macaques

KN Robillard, KM Lee, KB Chiu, AG MacLean - Brain, behavior, and …, 2016 - Elsevier
How aging impacts the central nervous system (CNS) is an area of intense interest. Glial
morphology is known to affect neuronal and immune function as well as metabolic and …

[HTML][HTML] Affordability, feasibility, and accessibility: Companion Animal guardians with (dis) abilities' access to veterinary medical and behavioral services during COVID …

H Wu, RS Bains, A Morris, C Morales - Animals, 2021 - mdpi.com
Simple Summary Compounding pre-existing diverse vulnerabilities, pet owners living with
(dis) abilities are expected to confront more challenges than their peers without (dis) …

[HTML][HTML] Age-related changes in microbial composition and function in cynomolgus macaques

J Duan, B Yin, W Li, T Chai, W Liang, Y Huang… - Aging (Albany …, 2019 - ncbi.nlm.nih.gov
Age can significantly affect human physiology and disease risk. Recent studies have shown
that age may affect the composition and function of the gut microbiota, but the underlying …

Cascading effects of social dynamics on the reproduction, survival, and population growth of mountain gorillas

RE Morrison, JP Hirwa, F Ndagijimana… - Animal …, 2023 - Wiley Online Library
Whilst the conservation impacts of density‐dependent population effects have been well
studied, the impact that socially‐driven changes (eg group fissions that increase group …