Copy number aberrations (CNA) are one of the most important classes of genomic mutations
related to oncogenetic effects. In the past three decades, a vast amount of CNA data has …

Abstract Background Cystic Fibrosis (CF) is a monogenic disease caused by mutations in
the gene coding the Cystic Fibrosis Transmembrane Regulator (CFTR) protein, but its …

The morphology of breast cancer cells is often used as an indicator of tumor severity and
prognosis. Additionally, morphology can be used to identify more fine-grained, molecular …

Modeling in systems biology: Causal understanding before prediction?: Patterns Skip to Main
Content Advertisement Patterns All content is freely available to readers and supported …

Clear cell renal cell carcinoma (ccRCC) tumours develop and progress via complex
remodelling of the kidney epigenome, transcriptome, proteome, and metabolome. Given the …

Understanding complex diseases requires approaches that jointly analyze omic data across
multiple biological layers, including signaling, gene regulation, and metabolism. Existing …

A prominent endophenotype in Autism Spectrum Disorder (ASD) is synaptic plasticity
dysfunction, yet the molecular mechanism remains elusive. As a prototype, we investigated …

Fibroblast heterogeneity is increasingly recognised across cancer conditions. Given their
important contribution to disease progression, mapping out fibroblasts' heterogeneity is …

High dimensional characterization of drug targets, compound effects and disease
phenotypes are crucial for increased efficiency of drug discovery. High-throughput gene …

Chronic kidney disease (CKD) affects more than 10% of the world's population and causes
millions of deaths annually. Organ fibrosis is the main driver of the pathology underlying …