[HTML][HTML] ATP ion channel P2X purinergic receptors in inflammation response
J Liu, S Liu, S Hu, J Lu, C Wu, D Hu, W Zhang - Biomedicine & …, 2023 - Elsevier
Different studies have confirmed that P2X purinergic receptors play a key role in
inflammation. Activation of P2X purinergic receptors can release inflammatory cytokines and …
inflammation. Activation of P2X purinergic receptors can release inflammatory cytokines and …
Mesenchymal stem cells transfer mitochondria to allogeneic Tregs in an HLA-dependent manner improving their immunosuppressive activity
K Piekarska, Z Urban-Wójciuk, M Kurkowiak… - Nature …, 2022 - nature.com
Cell-based immunotherapies can provide safe and effective treatments for various disorders
including autoimmunity, cancer, and excessive proinflammatory events in sepsis or viral …
including autoimmunity, cancer, and excessive proinflammatory events in sepsis or viral …
[HTML][HTML] eATP and autoimmune diabetes
C Loretelli, I Pastore, ME Lunati, A Abdelsalam… - Pharmacological …, 2023 - Elsevier
Purpose of review The purine nucleotide adenosine triphosphate (ATP) is released into
extracellular spaces as extracellular ATP (eATP) as a consequence of cell injury or death …
extracellular spaces as extracellular ATP (eATP) as a consequence of cell injury or death …
Operational tolerance after hematopoietic stem cell transplantation is characterized by distinct transcriptional, phenotypic, and metabolic signatures
L Dubouchet, H Todorov, R Seurinck, N Vallet… - Science Translational …, 2022 - science.org
The mechanisms underlying operational tolerance after hematopoietic stem cell
transplantation in humans are poorly understood. We studied two independent cohorts of …
transplantation in humans are poorly understood. We studied two independent cohorts of …
Increased P2X7 expression in the gastrointestinal tract and skin in a humanised mouse model of graft-versus-host disease
P Cuthbertson, SR Adhikary, NJ Geraghty… - Clinical …, 2020 - portlandpress.com
Background: Allogeneic haematopoietic stem cell transplantation (HSCT) is a curative
therapy for blood cancers; but results in the development of graft-versus-host disease …
therapy for blood cancers; but results in the development of graft-versus-host disease …
Self-Regulation of memory CD8 T cell metabolism through extracellular ATP signaling
KM Wanhainen, SC Jameson, HB da Silva - Immunometabolism, 2019 - journals.lww.com
Following activation, CD8 T cells transition from reliance on mitochondrial respiration to
increasing utilization of aerobic glycolysis. After the effector phase, however, reversion to …
increasing utilization of aerobic glycolysis. After the effector phase, however, reversion to …
Long-term treatment with the P2X7 receptor antagonist Brilliant Blue G reduces liver inflammation in a humanized mouse model of graft-versus-host disease
Allogeneic haematopoietic stem cell transplantation (HSCT) is a frequent curative therapy
for numerous haematological malignancies. However, HSCT is limited by the occurrence of …
for numerous haematological malignancies. However, HSCT is limited by the occurrence of …
Extracellular ATP activates P2X7R-NF-κB (p65) pathway to promote the maturation of bone marrow-derived dendritic cells of mice
Y Yu, S Feng, S Wei, Y Zhong, G Yi, H Chen, L Liang… - Cytokine, 2019 - Elsevier
The maturation state of dendritic cell (DC) plays an important role in immune activities.
Previously we had found that NF-κB (p65) pathway could promote DC maturation and …
Previously we had found that NF-κB (p65) pathway could promote DC maturation and …
Pharmacological blockade of the CD39/CD73 pathway but not adenosine receptors augments disease in a humanized mouse model of graft‐versus‐host disease
NJ Geraghty, D Watson… - Immunology and Cell …, 2019 - Wiley Online Library
Allogeneic hematopoietic stem cell transplantation is a curative therapy for a number of
hematological malignancies, but is limited by the development of graft‐versus‐host disease …
hematological malignancies, but is limited by the development of graft‐versus‐host disease …
Altered donor P2X7 activity in human leukocytes correlates with P2RX7 genotype but does not affect the development of graft-versus-host disease in humanised mice
SR Adhikary, NJ Geraghty, P Cuthbertson, R Sluyter… - Purinergic …, 2019 - Springer
Graft-versus-host disease (GVHD) is a life-threatening consequence of allogeneic
haematopoietic stem cell transplantation, a curative therapy for haematological …
haematopoietic stem cell transplantation, a curative therapy for haematological …