Although hormones such as glucocorticoids have been broadly accepted in recent decades
as general neuromodulators of memory processes, sex steroid hormones such as the potent …

Estrogen receptor-positive (ER+) is the most common subtype of breast cancer. Endocrine
therapy is the fundamental treatment against this entity, by directly or indirectly modifying …

Endometrial cancer is the most common gynecological cancer in the developed world, and it
is one of the few cancer types that is becoming more prevalent and leading to more deaths …

Obesity is a risk factor for estrogen receptor-positive (ER+) breast cancer after menopause.
The pro-proliferative effects of estrogens are well characterized and there is a growing body …

Gene expression data are accumulating exponentially in public repositories. Reanalysis and
integration of themed collections from these studies may provide new insights, but requires …

By eliciting distinct transcriptional responses, the oestrogen receptors (ERs) ERα and ERβ
exert opposite effects on cellular processes that include proliferation, apoptosis and …

Estrogen receptors (ERs) act by regulating transcriptional processes. The classical
mechanism of ER action involves estrogen binding to receptors in the nucleus, after which …

Although nonclassical estrogen actions initiated at the cell surface have been described in
many tissues, the identities of the membrane estrogen receptors (mERs) mediating these …

Steroid hormones exert profound effects on cell growth, development, differentiation, and
homeostasis. Their effects are mediated through specific intracellular steroid receptors that …

The adaptive responses of the body that maintain homeostasis in response to stressors can
be called “allostasis”, meaning “achieving stability through change”. Mediators produced by …