Oxidative stress‐related cellular aging causes dysfunction of the Kv3. 1/KCNC1 channel reverted by melatonin

S Spinelli, A Remigante, R Liuni, G Mantegna… - Aging …, 2024 - Wiley Online Library
Abstract The voltage‐gated Kv3. 1/KCNC1 channel is abundantly expressed in fast‐spiking
principal neurons and GABAergic inhibitory interneurons throughout the ascending auditory …

Combined genetic polymorphisms of the GSTT1 and NRF2 genes increase susceptibility to cisplatin-induced ototoxicity: A preliminary study

T Fujikawa, T Ito, R Okada, M Sawada, K Mohri… - Hearing Research, 2024 - Elsevier
Objective The genotype-phenotype relationship in cisplatin-induced ototoxicity remains
unclear. By assessing early shifts in distortion product otoacoustic emission (DPOAE) levels …

[HTML][HTML] Early-Onset Hearing Loss in Mouse Models of Alzheimer's Disease and Increased DNA Damage in the Cochlea

JH Park, BD Sahbaz, K Pekhale, X Chu, MN Okur… - Aging …, 2024 - ncbi.nlm.nih.gov
There is considerable interest in whether sensory deficiency is associated with the
development of Alzheimer's disease (AD). Notably, the relationship between hearing …