[HTML][HTML] Geniposide alleviates oxidative stress of mice with depression-like behaviors by upregulating Six3os1

T Zou, K Sugimoto, J Zhang, Y Liu, Y Zhang… - Frontiers in Cell and …, 2020 - frontiersin.org
Depression is a major cause of disease burden and severely impairs well-being of patients
around the globe. Geniposide (GP) has been revealed to play a significant role in …

Avicularin attenuates memory impairment in rats with amyloid beta-induced Alzheimer's disease

NP Samant, GL Gupta - Neurotoxicity research, 2022 - Springer
Amyloid-beta-induced Alzheimer's disease (AD) and its further complications are well-
established models in preclinical studies and demonstrated by many researchers …

[HTML][HTML] Brain-derived neurotrophic factor dysregulation as an essential pathological feature in Huntington's disease: mechanisms and potential therapeutics

A Speidell, N Bin Abid, H Yano - Biomedicines, 2023 - mdpi.com
Brain-derived neurotrophic factor (BDNF) is a major neurotrophin whose loss or interruption
is well established to have numerous intersections with the pathogenesis of progressive …

[HTML][HTML] Chronic AdipoRon treatment mimics the effects of physical exercise on restoring hippocampal neuroplasticity in diabetic mice

TH Lee, Ahadullah, BR Christie, K Lin, PM Siu… - Molecular …, 2021 - Springer
Administration of exercise mimetic drugs could be a novel therapeutic approach to combat
comorbid neurodegeneration and metabolic syndromes. Adiponectin is an adipocyte …

Receptor for advanced glycation end products aggravates cognitive deficits in type 2 diabetes through binding of C‐terminal AAs 2‐5 to mitogen‐activated protein …

XY Zhou, CJ Ying, B Hu, YS Zhang, T Gan, YD Zhu… - Aging …, 2022 - Wiley Online Library
In this study, we explored the precise mechanisms underlying the receptor for advanced
glycation end products (RAGE)‐mediated neuronal loss and behavioral dysfunction induced …

Paeonol ameliorates diabetic erectile dysfunction by inhibiting HMGB1/RAGE/NF‐kB pathway

T Sun, W Xu, J Wang, J Song, T Wang, S Wang… - …, 2023 - Wiley Online Library
Background The management of diabetes mellitus‐induced erectile dysfunction (DMED) is
progressively becoming tricky due to the surge in the number of patients and the poor …

Time-dependent effects of platelet-rich plasma on the memory and hippocampal synaptic plasticity impairment in vascular dementia induced by chronic cerebral …

M Bayat, S Zabihi, N Karbalaei, M Haghani - Brain research bulletin, 2020 - Elsevier
The present study aimed to investigate the effects of early and late administration of platelet-
rich plasma (PRP) on learning-memory and hippocampal synaptic plasticity impairment in …

Remedial effects of caffeine against depressive-like behaviour in mice by modulation of neuroinflammation and BDNF

S Basu Mallik, J Mudgal, S Hall, M Kinra… - Nutritional …, 2022 - Taylor & Francis
Objective: Caffeine (CAF) is one of the most commonly consumed nutritional stimulant in
beverages. Interestingly, CAF produces varied effects in a dose-dependent manner, and that …

[HTML][HTML] Arc regulates transcription of genes for plasticity, excitability and Alzheimer's disease

HW Leung, G Foo, A VanDongen - Biomedicines, 2022 - mdpi.com
The immediate early gene Arc is a master regulator of synaptic function and a critical
determinant of memory consolidation. Here, we show that Arc interacts with dynamic …

[HTML][HTML] Serum NLRP3 inflammasome and BDNF: potential biomarkers differentiating reactive and endogenous depression

XJ Yang, BC Zhao, J Li, C Shi, YQ Song… - Frontiers in …, 2022 - frontiersin.org
Background The highly heterogeneous pathogenesis of depression and limited response to
current antidepressants call for more objective evidence for depression subtypes. Reactive …