Background In studies exploring the effects of HCMV infection on immune system aging
('immunosenescence'), after organ transplantation or in other settings, HCMV-specific T-cell …

We recommend that clinicians tailor their approach to the individual based on their
underlying immune deficit and maintain a high index of suspicion and low threshold for …

Lactate–proton symporter monocarboxylate transporter 1 (MCT1) facilitates lactic acid export
from T cells. Here, we report that MCT1 is mandatory for the development of virus-specific …

Introduction The present work sought to identify MHC-I-restricted peptide signatures for
arbovirus using in silico and in vitro peptide microarray tools. Methods First, an in-silico …

The equine population in the United States and worldwide now includes a higher
percentage of geriatric horses than ever previously recorded, and as methods to treat and …

The generation of a functional memory T cell pool upon primary encounter with an infectious
pathogen is, in combination with humoral immunity, an essential process to confer protective …

New infections in general, and new viral infections amongst them, represent a serious
challenge to an older organism. This review discusses the age-related alterations in …

Advancing age is accompanied by profound changes in immune function; some are induced
by the loss of critical niches that support development of naïve cells (eg thymic involution) …

In experimental models in which the Ag-stimulation history of memory CD8 T cell
populations was clearly defined (adoptive transfer of a known number of TCR-transgenic …

The immune response is remodeled with aging in a process called immunosenescence.
Some immunologists conceive immunosenescence as an adaptation of immunity to the …