Methods have been developed to transfect immunoglobulin genes into lymphoid cells. The
transfected genes are faithfully expressed, and assembly can occur both between the …

For a divalent molecule of mol. wt 150,000, IgG (Fig. 1) is required to interact with a
seemingly large number of different molecular species. Antigen is recognised by sites on the …

This comprehensive reference collects fundamental theories and recent research from a
wide range of fields including biology, biochemistry, physics, applied mathematics, and …

The denaturation of immunoglobulin G was studied by different calorimetric methods and
circular dichroism spectroscopy. The thermogram of the immunoglobulin showed two main …

In humoral defence, pathogens are cleared by antibodies acting as adaptor molecules: they
bind to antigen and trigger clearance mechanisms such as phagocytosis, antibody …

The availability of monoclonal antibodies has revived interest in immunotherapy. The ability
to influence an individual's immune state by administering immunoglobulin of the …

Presenting a wide-ranging view of current developments in protein research, the papers in
this collection, each written by highly regarded experts in the field, examine various aspects …

Myasthenia gravis (MG) is a severely debilitating autoimmune disease that is due to a
decrease in the efficiency of synaptic transmission at neuromuscular synapses. MG is …

Results of clinical trials have indicated that cA2, a neutralizing mouse/human IgG1 chimeric
anti-human TNF-α monoclonal antibody, may have therapeutic benefit for rheumatoid …

Although very similar in sequence, the four subclasses of human immunoglobulin G (IgG)
differ markedly in their ability to activate complement. Glu318-Lys320-Lys322 has been …