Understanding cancer and the anticancer activities of naphthoquinones–a review

KW Wellington - RSC advances, 2015 - pubs.rsc.org
The non-communicable disease, cancer, is one of the major causes of death across the
world and is forecast to increase by 75% to reach close to 25 million cases over the next two …

[PDF][PDF] The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases-part II

TJ Schmidt, SA Khalid, ÁJ Romanha, TMA Alves… - 2012 - lavierebelle.org
Infections with protozoan parasites are a major cause of disease and mortality in many
tropical countries of the world. Diseases caused by species of the genera Trypanosoma …

[HTML][HTML] The antifungal activity of naphthoquinones: An integrative review

PG FERREIRA, CD NICOLETTI… - Anais da Academia …, 2018 - SciELO Brasil
Naphthoquinones are the most commonly occurring type of quinones in nature. They are a
diverse family of secondary metabolites that occur naturally in plants, lichens and various …

Naphthoquinones and their derivatives: emerging trends in combating microbial pathogens

NS Mone, SA Bhagwat, D Sharma, M Chaskar… - Coatings, 2021 - mdpi.com
In the current era, an ever-emerging threat of multidrug-resistant (MDR) pathogens pose
serious health challenges to mankind. Researchers are uninterruptedly putting their efforts …

Beta-lapachone: Natural occurrence, physicochemical properties, biological activities, toxicity and synthesis

CL Gomes, VAW Sales, CG de Melo, RMF da Silva… - Phytochemistry, 2021 - Elsevier
Abstract β-Lapachone is an ortho-naphthoquinone originally isolated from the heartwood of
Handroanthus impetiginosus and can be obtained through synthesis from lapachol …

Lawsone in organic synthesis

AK Jordão, MD Vargas, AC Pinto, FC da Silva… - RSC …, 2015 - pubs.rsc.org
Lawsone (1) is a special naphthoquinone that is useful for many applications in various
scientific and technological fields. For over 100 years, it has been used as the starting …

Synthesis of quinones with highlighted biological applications: A critical update on the strategies towards bioactive compounds with emphasis on lapachones

EN da Silva Júnior, GAM Jardim, C Jacob… - European Journal of …, 2019 - Elsevier
Naphthoquinones are of key importance in organic synthesis and medicinal chemistry. In the
last few years, various synthetic routes have been developed to prepare bioactive …

Synthesis of quinoidal molecules: strategies towards bioactive compounds with an emphasis on lapachones

SL de Castro, FS Emery, EN da Silva Junior - European journal of …, 2013 - Elsevier
Naphthoquinoidal compounds are of great interest in medicinal chemistry. In recent years,
several synthetic routes have been developed to obtain bioactive molecules derived from …

Two diseases, one approach: multitarget drug discovery in Alzheimer's and neglected tropical diseases

F Prati, E Uliassi, ML Bolognesi - MedChemComm, 2014 - pubs.rsc.org
In the past decade, scientific advances in network pharmacology have laid the foundations
for a polypharmacological approach to discover new drugs for complex diseases. There is …

Chiral squaramide-catalyzed asymmetric synthesis of pyranones and pyranonaphthoquinones via cascade reactions of 1, 3-dicarbonyls with Morita–Baylis–Hillman …

DK Nair, RFS Menna-Barreto… - Chemical …, 2014 - pubs.rsc.org
Cascade reactions of 1, 3-dicarbonyls with Morita–Baylis–Hillman acetates of nitroalkenes
using a quinine derived chiral squaramide organocatalyst led to the formation of pyranones …