Function and therapeutic value of astrocytes in neurological diseases

HG Lee, MA Wheeler, FJ Quintana - Nature reviews Drug discovery, 2022 - nature.com
Astrocytes are abundant glial cells in the central nervous system (CNS) that perform diverse
functions in health and disease. Astrocyte dysfunction is found in numerous diseases …

Astrocyte crosstalk in CNS inflammation

M Linnerbauer, MA Wheeler, FJ Quintana - Neuron, 2020 - cell.com
Astrocytes control multiple processes in the nervous system in health and disease. It is now
clear that specific astrocyte subsets or activation states are associated with specific genomic …

The role of astrocytes in CNS inflammation

F Giovannoni, FJ Quintana - Trends in immunology, 2020 - cell.com
Astrocytes are the most abundant cell type in the central nervous system (CNS), performing
complex functions in health and disease. It is now clear that multiple astrocyte subsets or …

Inflammation from peripheral organs to the brain: how does systemic inflammation cause neuroinflammation?

Y Sun, Y Koyama, S Shimada - Frontiers in aging neuroscience, 2022 - frontiersin.org
As inflammation in the brain contributes to several neurological and psychiatric diseases,
the cause of neuroinflammation is being widely studied. The causes of neuroinflammation …

The aryl hydrocarbon receptor: an environmental sensor integrating immune responses in health and disease

V Rothhammer, FJ Quintana - Nature Reviews Immunology, 2019 - nature.com
The environment, diet, microbiota and body's metabolism shape complex biological
processes in health and disease. However, our understanding of the molecular pathways …

Role of inflammation in diabetic retinopathy

A Rübsam, S Parikh, PE Fort - International journal of molecular sciences, 2018 - mdpi.com
Diabetic retinopathy is a common complication of diabetes and remains the leading cause of
blindness among the working-age population. For decades, diabetic retinopathy was …

Protective functions of reactive astrocytes following central nervous system insult

M Linnerbauer, V Rothhammer - Frontiers in immunology, 2020 - frontiersin.org
Astrocytes play important roles in numerous central nervous system disorders including
autoimmune inflammatory, hypoxic, and degenerative diseases such as Multiple Sclerosis …

The glymphatic system (en) during inflammation

FLH Mogensen, C Delle, M Nedergaard - International journal of …, 2021 - mdpi.com
The glymphatic system is a fluid-transport system that accesses all regions of the brain. It
facilitates the exchange of cerebrospinal fluid and interstitial fluid and clears waste from the …

Cytokine networks in neuroinflammation

B Becher, S Spath, J Goverman - Nature Reviews Immunology, 2017 - nature.com
Cytokines provide cells with the ability to communicate with one another and orchestrate
complex multicellular behaviour. There is an emerging understanding of the role that …

The role of astrocytes in multiple sclerosis

G Ponath, C Park, D Pitt - Frontiers in immunology, 2018 - frontiersin.org
The role traditionally assigned to astrocytes in the pathogenesis of multiple sclerosis (MS)
lesions has been the formation of the glial scar once inflammation has subsided. Astrocytes …