A permethrin metabolite is associated with adaptive immune responses in Gulf War Illness

U Joshi, A Pearson, JE Evans, H Langlois… - Brain, behavior, and …, 2019 - Elsevier
Abstract Gulf War Illness (GWI), affecting 30% of veterans from the 1991 Gulf War (GW), is a
multi-symptom illness with features similar to those of patients with autoimmune diseases …

The neuroprotective role of reactive astrocytes after central nervous system injury

AG Boghdadi, L Teo, JA Bourne - Journal of Neurotrauma, 2020 - liebertpub.com
Reactive astrocytes have traditionally been viewed as a significant contributor to secondary
neuronal damage and repair inhibition after central nervous system (CNS) injury attributed …

[HTML][HTML] Fluctuations in glucose levels induce glial toxicity with glutamatergic, oxidative and inflammatory implications

A Quincozes-Santos, LD Bobermin, AM de Assis… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Astrocytes are dynamic cells that maintain brain homeostasis by regulating neurotransmitter
systems, antioxidant defenses, inflammatory responses and energy metabolism. Astroglial …

The multifaceted neurotoxicity of astrocytes in ageing and age-related neurodegenerative diseases: a translational perspective

DS Bouvier, S Fixemer, T Heurtaux, F Jeannelle… - Frontiers in …, 2022 - frontiersin.org
In a healthy physiological context, astrocytes are multitasking cells contributing to central
nervous system (CNS) homeostasis, defense, and immunity. In cell culture or rodent models …

Exercise-induced modulation of neuroinflammation in models of Alzheimer's disease

AM Kelly - Brain plasticity, 2018 - content.iospress.com
Abstract Alzheimer's disease (AD), a progressive, neurodegenerative condition
characterised by accumulation of toxic βeta-amyloid (Aβ) plaques, is one of the leading …

The NLRP3 inflammasome in neurodegenerative disorders: insights from epileptic models

L Palumbo, M Carinci, A Guarino, L Asth, S Zucchini… - Biomedicines, 2023 - mdpi.com
Neuroinflammation represents a dynamic process of defense and protection against the
harmful action of infectious agents or other detrimental stimuli in the central nervous system …

The function of astrocytes and their role in neurological diseases

WQ Yuan, WP Huang, YC Jiang, H Xu… - European Journal of …, 2023 - Wiley Online Library
Astrocytes have countless links with neurons. Previously, astrocytes were only considered a
scaffold of neurons; in fact, astrocytes perform a variety of functions, including providing …

Gut microbiota and neuroinflammation in pathogenesis of hypertension: A potential role for hydrogen sulfide

BD Ayaz, J Zubcevic - Pharmacological research, 2020 - Elsevier
Inflammation and gut dysbiosis are hallmarks of hypertension (HTN). Hydrogen sulfide (H 2
S) is an important freely diffusing molecule that modulates the function of neural …

Comparison of PPAR ligands as modulators of resolution of inflammation, via their influence on cytokines and oxylipins release in astrocytes

DV Chistyakov, AA Astakhova, SV Goriainov… - International journal of …, 2020 - mdpi.com
Neuroinflammation is a key process of many neurodegenerative diseases and other brain
disturbances, and astrocytes play an essential role in neuroinflammation. Therefore, the …

Astrocytes to the rescue! Glia limitans astrocytic endfeet control CNS inflammation

FJ Quintana - The Journal of clinical investigation, 2017 - Am Soc Clin Investig
The blood-brain barrier (BBB) and the glia limitans serve to prevent the migration of cells
and other large molecules from the blood into the CNS. Neuroinflammatory diseases are …