Purpose Patients with acute myeloid leukemia (AML) and FLT3/internal tandem duplication
(FLT3/ITD) have poor prognosis if treated with chemotherapy only. Whether this alteration …

Core binding factor acute myelogenous leukemia (CBF-AML), characterized by the
presence of either t (8; 21)(q22; q22) or inv (16)(p13q22)/t (16; 16), is considered good-risk …

Acute myeloid leukemia (AML) is the most common acute leukemia in adults that affects the
myeloid lineage. The recent advances have upgraded our understanding of the cytogenetic …

Clonal cytogenetic evolution with additional chromosomal abnormalities (ACAs) in chronic
myelogenous leukemia (CML) is generally associated with decreased response to tyrosine …

Pediatric acute myeloid leukemia is a rare and heterogeneous disease in relation to
morphology, immunophenotyping, germline and somatic cytogenetic and genetic …

Introduction: Acute myeloid leukemia (AML) is the most common acute forms of leukemia in
adults. It has a poor long-term survival with a high relapse rate and at relapse, is commonly …

We investigated ten–eleven translocation 2 (TET2) mutations in acute myeloid leukemia
(AML), their correlation with other gene mutations and prognostic value. By deep …

Purpose To determine the frequency of DNMT3A mutations, their associations with clinical
and molecular characteristics and outcome, and the associated gene-and microRNA …

The karyotype is so far the most important prognostic parameter in acute myeloid leukemia
(AML). Molecular mutations have been analyzed to subdivide AML with normal karyotype …

Purpose The current European LeukemiaNet (ELN) recommendations for acute myeloid
leukemia (AML) propose a new risk reporting system, integrating molecular and cytogenetic …