Conditioning intensity and peritransplant flow cytometric MRD dynamics in adult AML

G Paras, LM Morsink, M Othus, F Milano… - Blood, The Journal …, 2022 - ashpublications.org
In acute myeloid leukemia (AML), measurable residual disease (MRD) before or after
allogeneic hematopoietic cell transplantation (HCT) is an established independent indicator …

Initial diagnostic workup of acute leukemia: guideline from the College of American Pathologists and the American Society of Hematology

DA Arber, MJ Borowitz, M Cessna… - … of pathology & …, 2017 - meridian.allenpress.com
Context.—A complete diagnosis of acute leukemia requires knowledge of clinical
information combined with morphologic evaluation, immunophenotyping and karyotype …

The level of residual disease based on mutant NPM1 is an independent prognostic factor for relapse and survival in AML

N Shayegi, M Kramer, M Bornhäuser… - Blood, The Journal …, 2013 - ashpublications.org
Mutations of the NPM1 gene (NPM1 mut) are among the most common genetic alterations in
acute myeloid leukemia and are suitable for minimal residual disease detection. We …

Integrated stem cell signature and cytomolecular risk determination in pediatric acute myeloid leukemia

BJ Huang, JL Smith, JE Farrar, YC Wang… - Nature …, 2022 - nature.com
Relapsed or refractory pediatric acute myeloid leukemia (AML) is associated with poor
outcomes and relapse risk prediction approaches have not changed significantly in …

Measurable residual disease, conditioning regimen intensity, and age predict outcome of allogeneic hematopoietic cell transplantation for acute myeloid leukemia in …

MH Gilleece, M Labopin, I Yakoub‐Agha… - American journal of …, 2018 - Wiley Online Library
Patients with acute myeloid leukemia (AML) in morphological first complete remission (CR1)
pre‐allogeneic hematopoietic cell transplantation (HCT) may have measurable residual …

CBFB-MYH11 fusion neoantigen enables T cell recognition and killing of acute myeloid leukemia

MA Biernacki, KA Foster, KB Woodward… - The Journal of …, 2020 - Am Soc Clin Investig
Proteins created from recurrent fusion genes like CBFB-MYH11 are prevalent in acute
myeloid leukemia (AML), often necessary for leukemogenesis, persistent throughout the …

Secondary genetic lesions in acute myeloid leukemia with inv (16) or t (16; 16): a study of the German-Austrian AML Study Group (AMLSG)

P Paschka, J Du, RF Schlenk, VI Gaidzik… - Blood, The Journal …, 2013 - ashpublications.org
In this study, we evaluated the impact of secondary genetic lesions in acute myeloid
leukemia (AML) with inv (16)(p13. 1q22) or t (16; 16)(p13. 1; q22); CBFB-MYH11. We …

Advances in acute myeloid leukemia: recently approved therapies and drugs in development

M Stanchina, D Soong, B Zheng-Lin, JM Watts, J Taylor - Cancers, 2020 - mdpi.com
Simple Summary Acute myeloid leukemia (AML) is one of the most common types of
leukemia in adults, with an average first diagnosis at age 68, and has historically carried …

CD36 drives metastasis and relapse in acute myeloid leukemia

T Farge, J Nakhle, D Lagarde, G Cognet, N Polley… - Cancer Research, 2023 - AACR
Identifying mechanisms underlying relapse is a major clinical issue for effective cancer
treatment. The emerging understanding of the importance of metastasis in hematologic …

Resistance prediction in AML: analysis of 4601 patients from MRC/NCRI, HOVON/SAKK, SWOG and MD Anderson Cancer Center

RB Walter, M Othus, AK Burnett, B Löwenberg… - Leukemia, 2015 - nature.com
Therapeutic resistance remains the principal problem in acute myeloid leukemia (AML). We
used area under receiver-operating characteristic curves (AUCs) to quantify our ability to …