Pain is the cancer-related event that is most disruptive to the cancer patient's quality of life.
Although bone cancer pain is one of the most severe and common of the chronic pains that …

Many cancers have a strong propensity to spread to bone. The processes involved in cancer
dissemination to bone are complex and variable, and the changes in bone metabolism …

Although skeletal pain plays a major role in reducing the quality of life in patients suffering
from osteoarthritis, Paget's disease, sickle cell anemia and bone cancer, little is known about …

Pain is the most common presenting symptom in patients with bone cancer and bone cancer
pain can be both debilitating and difficult to control fully. To begin to understand the …

Bone metastases profoundly perturb normal bone remodeling. Biochemical markers of bone
turnover have been shown to reflect these tumor-induced changes in bone remodeling and …

More than 1.3 million cases of cancer will be diagnosed in 2006 in the United States alone,
and 90% of patients with advanced cancer will experience significant, life-altering cancer …

This review relates to the efficacy and safety of bisphosphonates in metastatic bone disease.
It discusses practical recommendations and possible future indications for bisphosphonate …

The bisphosphonates pamidronate and clodronate are most often used in oncology. Newer,
more potent compounds under study are ibandronate and zoledronate. The main route of …

INVESTIGATIONS ON the pathogenesis of cancer metastasis to bone have received
increased attention by scientists worldwide. This is good news for patients that suffer from …

The metastasis of breast cancer to the skeleton is a serious clinical problem resulting in
hypercalcemia, bone fragility and insurmountable pain. The invasion of bony tissue by …