It is common to experience a thumping heart during strenuous exercise or when frightened.
This increase in the force and frequency of contraction of the heart can result in an increase …

The modern β‐adrenergic agonists (β‐blockers) possess one or more than one chiral center
in their structure. Two enantiomers exhibit distinct pharmacodynamic and pharmacokinetic …

The development of pacing-induced heart failure was studied in chronically instrumented,
conscious dogs paced at a rate of 240 beats/min for 1 d (n= 6), 1 wk (n= 6), and 3-4 wk (n …

The 2.4 Å crystal structure of the β2‐adrenergic receptor (β2AR) in complex with the high‐
affinity inverse agonist (−)‐carazolol provides a detailed structural framework for the analysis …

The basic pharmacokinetics of bisoprolol were investigated in three independent studies
involving 23 healthy volunteers. After administering 20 mg of 14C‐bisoprolol orally, mean …

A randomized, placebo-controlled, double-blind crossover investigation in 12 patients with
non-asthmatic chronic obstructive lung disease and co-existing stable angina pectoris was …

Human myocardial beta-adrenergic receptors were directly identified and characterized
using the high affinity antagonist radioligand [125 I] iodocyanopindolol. Beta 1 and beta 2 …

A sensitive, specific and selective liquid chromatography/tandem mass spectrometric
method has been developed and validated for the simultaneous determination of irbesartan …

Beta-adrenoceptor blocking drugs can be characterised by their pharmacokinetic properties.
One of the most important factors appears to be lipid solubility. Lipophilic beta-adrenoceptor …

We studied the alterations in myocardial beta-adrenergic receptor-adenylate cyclase activity
and muscarinic receptor density in a canine model of left ventricular (LV) failure. LV failure …