An HPLC method capable of determining bisoprolol in bulk substance in the presence of its
synthetic intermediates, which are potential impurities, is described. To choose the optimum …

PET-investigations of β-adrenoceptors in heart, lungs, and brain are of great clinical interest.
Receptor densities are altered under various pathophysiological conditions. This review …

The binding properties of a newly developed, highly selective β 1-adrenoceptor antagonist
radioligand,(−)[3 H] bisoprolol (EMD 33512) were investigated in rabbit lung membranes …

The autonomic nervous system is the major system extrinsic to the heart which regulates
myocardial contractility. This system can be subdivided on the basis of anatomy, functional …

Adrenergic dysfunction in uremia has been well described. Several lines of evidence
suggest disorders of blood pressure regulation and myocardial response may occur …

Conversion of phosphorylase b to a which is catalyzed by the enzyme phosphorylase kinase
is known to require Ca++. Trifluoperazine, an inhibitor of calmodulin-dependent enzymes …

The autonomic nervous system is the major system extrinsic to the heart that regulates
myocardial contractility. This system can be subdivided on the basis of anatomy, functional …

The cardiac alpha adrenergic receptor has been identified in previous studies with tritiated
radioligands. However, tritiated radioligands which are relatively low in specific activity, may …

In an initial double-blind randomized study with three parallel groups, 48 patients, mean age
49.6 years (32-65 years), with hypertension WHO I-II, were given bisoprolol in doses of 5 …

Introduction When the no observed adverse effect level (NOAEL) is determined by
respiratory safety pharmacology, follow-up studies are warranted and may include airway …