Relapse of patients with chronic myelogenous leukemia (CML) may occur at least partially
because leukemia stem cells (LSCs) lack sensitivity to tyrosine kinase inhibitors (TKIs) such …

Although cell lineage information is fundamental to understanding organismal development,
very little direct information is available for humans. We performed high-depth (250×) whole …

Cancer is driven by somatic mutations that provide a fitness advantage. While targeted
therapies often focus on the mutated gene or its direct downstream effectors, imbalances …

CRISPR-based screening methods using single-cell RNA sequencing (scRNA-seq)
technology enable comprehensive profiling of gene perturbations from knock-out mutations …

The glucagon-like peptide-1 receptor (GLP-1R) plays a key role in metabolism and is an
important therapeutic target in diabetes and obesity. Recent studies in experimental animals …

The molecular pathogenesis of hematological diseases is often driven by genetic and
epigenetic alterations. Next-generation sequencing has considerably increased our …

The rise of longitudinal single-cell sequencing experiments on patient-derived cell cultures,
xenografts and organoids is opening new opportunities to track cancer evolution, assess the …

Clonal evolution represents the natural process through which cancer cells continuously
search for phenotypic advantages that enable them to develop and expand within …

Nearly every mammalian cell division is accompanied by a mutational event that becomes
fixed in a daughter cell. When carried forward to additional cell progeny, a clone of variant …

Every cell in the human brain possesses a unique genome that is the product of the
accumulation of somatic mutations starting from the first postzygotic cell division and …