[HTML][HTML] New strategies and perspectives on managing IgA nephropathy

H Selvaskandan, CK Cheung, M Muto… - Clinical and experimental …, 2019 - Springer
IgA nephropathy is an inflammatory renal disease characterised by the deposition of IgA in
the glomerular mesangium and is the most commonly reported primary glomerulonephritis …

[HTML][HTML] Perspectives on how mucosal immune responses, infections and gut microbiome shape IgA nephropathy and future therapies

JW He, XJ Zhou, JC Lv, H Zhang - Theranostics, 2020 - ncbi.nlm.nih.gov
Infections have been considered to play a critical role in the pathogenesis of IgA
nephropathy (IgAN) because synpharyngitic hematuria is a common feature in IgAN …

IgA vasculitis with nephritis: update of pathogenesis with clinical implications

MC Hastings, DV Rizk, K Kiryluk, R Nelson, RS Zahr… - Pediatric …, 2022 - Springer
IgA vasculitis with nephritis (IgAVN) shares many pathogenetic features with IgA
nephropathy (IgAN). The purpose of this review is to describe our current understanding of …

[HTML][HTML] The contribution of complement to the pathogenesis of IgA nephropathy: are complement-targeted therapies moving from rare disorders to more common …

F Poppelaars, B Faria, W Schwaeble… - Journal of clinical …, 2021 - mdpi.com
Primary IgA nephropathy (IgAN) is a leading cause of chronic kidney disease and kidney
failure for which there is no disease-specific treatment. However, this could change, since …

[HTML][HTML] Aberrantly glycosylated IgA1 in IgA nephropathy: What we know and what we don't know

Y Ohyama, MB Renfrow, J Novak… - Journal of Clinical …, 2021 - mdpi.com
IgA nephropathy (IgAN), the most common primary glomerular disease worldwide, is
characterized by glomerular deposition of IgA1-containing immune complexes. The IgA1 …

Immunological drivers of IgA nephropathy: Exploring the mucosa–kidney link

H Selvaskandan, J Barratt… - International Journal of …, 2022 - Wiley Online Library
IgA nephropathy (IgAN) is the most common pattern of primary glomerular disease reported
worldwide. Up to 40% of those with IgAN progress to end‐stage kidney disease within 20 …

[HTML][HTML] IgA vasculitis and IgA nephropathy: same disease?

E Pillebout - Journal of clinical medicine, 2021 - mdpi.com
Many authors suggested that IgA Vasculitis (IgAV) and IgA Nephropathy (IgAN) would be
two clinical manifestations of the same disease; in particular, that IgAV would be the …

Markers for the progression of IgA nephropathy

D Maixnerova, C Reily, Q Bian, M Neprasova… - Journal of …, 2016 - Springer
We have summarized the latest findings on markers for progression of immunoglobulin A
(IgA) nephropathy (IgAN), the most common primary glomerulonephritis with a high …

Targeting complement in IgA nephropathy

F Caravaca-Fontán, E Gutiérrez… - Clinical Kidney …, 2023 - academic.oup.com
Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis
worldwide. Recent years have witnessed significant improvements in the understanding of …

[HTML][HTML] Be on target: strategies of targeting alternative and lectin pathway components in complement-mediated diseases

J Dobó, A Kocsis, P Gál - Frontiers in immunology, 2018 - frontiersin.org
The complement system has moved into the focus of drug development efforts in the last
decade, since its inappropriate or uncontrolled activation has been recognized in many …