Introduction Crescents, especially those found at a percentage greater than 50%, are often
associated with rapid progression of kidney disease in IgA nephropathy (IgAN). The …

Properdin, the widely known positive regulator of the alternative pathway (AP), has
undergone significant investigation over the last decade to define its function in inflammation …

Background IgA nephropathy is the most common glomerulonephritis world‐wide. IgA
nephropathy causes end‐stage kidney disease (ESKD) in 15% to 20% of affected patients …

Pemphigoid diseases are autoimmune chronic inflammatory skin diseases, which are
characterized by blistering of the skin and/or mucous membranes, and circulating and tissue …

Background: IgA nephropathy, a frequent cause of end-stage renal disease, is an
autoimmune disease wherein immune complexes consisting of IgA1 with galactose-deficient …

The glomerulus is the functional unit for filtration of blood and formation of primary urine.
This intricate structure is composed of the endothelium with its glycocalyx facing the blood …

Over the past decade, genome-wide association studies (GWAS) have emerged as a
powerful tool to understand the genetic basis of complex traits in humans. The GWAS …

Introduction IgA nephropathy (IgAN) is characterized by glomerular deposition of galactose-
deficient IgA1 and complement proteins and leads to renal impairment. Complement …

Complement factor C4d was recently observed in renal biopsies from patients who had IgA
nephropathy and a poor prognosis. We previously reported that C4d is a common …

Background: IgA nephropathy (IgAN) is the most frequent type of primary glomerulonephritis
since the first type was described more than four decades ago. It is the prevalent cause of …