The complement (C) cascade is an ancient system of proteins whose primary role is to
initiate and modulate immune responses. During C activation, circulating proteins are …

The alternative pathway is a continuously active surveillance arm of the complement system,
and it can also enhance complement activation initiated by the classical and the lectin …

The glomerulus is the functional unit for filtration of blood and formation of primary urine.
This intricate structure is composed of the endothelium with its glycocalyx facing the blood …

Glomerulonephritis (GN) refers to a group of renal diseases affecting the glomeruli due to
the damage mediated by immunological mechanisms. A large proportion of the disease …

Podocytes are differentiated epithelial cells which play an essential role to ensure a normal
function of the glomerular filtration barrier (GFB). In addition to their adhesive properties in …

We aimed to determine the relative contribution of each complement (C3 and C4d)
deposition to the progression of IgA nephropathy (IgAN). We enrolled a total of 380 patients …

The complement system plays a key pathogenic role in glomerular diseases with a diverse
range of aetiologies, including C3 glomerulopathy, immunoglobulin A nephropathy …

IgA Nephropathy (IgAN) is the most common cause of primary glomerulonephritis
worldwide. Despite the histopathologic hallmark of mesangial IgA deposition, IgAN is a …

An intronic variant at the complement factor H (CFH) gene on chromosome 1q32
(rs6677604) associates with risk of IgA nephropathy (IgAN), but the association signal has …

Background/Aims: There is an increasing risk of end-stage renal disease (ESRD) among
Asian people with immunoglobulin A nephropathy (IgAN). A computer-aided system for …