Background: The administration of corticosteroids in addition to supportive care to delay
progressive immunoglobulin A nephropathy (IgAN), the most common primary …

It was reported that histopathologic lesions are risk factors for the progression of IgA
Nephropathy (IgAN). The aim of this study was to investigate the relationships between …

Evidence has been furnished that immune cells, and immune-podocytes interactions have
increasingly become the focus of proteinuric kidney diseases, which affect millions of …

IgA nephropathy (IgAN) is the most common glomerular disease worldwide, with an
estimated annual incidence of 25 per million adults. Despite optimized supportive care …

Complement activation occurs in many glomerular diseases, the exact pathway (s) of
activation has been studied in detail in some diseases but not in all. C4d is generated by the …

Immunoglobulin A nephropathy (IgAN) remains the leading cause of primary glomerular
disease worldwide. Outcomes are poor with high rates of progressive chronic kidney …

Introduction Patients with IgA nephropathy (IgAN) have elevated serum levels of galactose-
deficient IgA1 (Gd-IgA1) that are bound by Gd-IgA1–specific autoantibodies in pathogenic …

Inflammatory liver diseases, including nonalcoholic steatohepatitis (NASH), alcohol-
associated liver disease (ALD), hepatitis C virus (HCV), and ALD/HCV, account for nearly 2 …

Human IgA is comprised of two subclasses, IgA1 and IgA2. Monomeric IgA (mIgA),
polymeric IgA (pIgA), and secretory IgA (SIgA) are the main molecular forms of IgA. The …

Genome-wide association studies (GWAS) had discovered several genetic risk loci for IgA
nephropathy (IgAN), where the susceptibility genes of CARD9 and HORMAD2 for IgAN were …