Polyhydroxylated Metallofullerenols Stimulate IL‐1β Secretion of Macrophage through TLRs/MyD88/NF‐κB Pathway and NLRP3 Inflammasome Activation
A number of functionalized fullerene derivatives have been widely investigated in biological
applications after the main problem of poor solubility in the cellular environment was solved …
applications after the main problem of poor solubility in the cellular environment was solved …
Targeting TLR/IL‐1R signalling in human diseases
M Loiarro, V Ruggiero, C Sette - Mediators of inflammation, 2010 - Wiley Online Library
The members of Toll‐like receptor/Interleukin (IL)‐1 receptor (TLR/IL‐1R) superfamily play a
fundamental role in the immune response. These receptors detect microbial components …
fundamental role in the immune response. These receptors detect microbial components …
[HTML][HTML] Myeloid-Specific Rictor Deletion Induces M1 Macrophage Polarization and Potentiates In Vivo Pro-Inflammatory Response to Lipopolysaccharide
WT Festuccia, P Pouliot, I Bakan, DM Sabatini… - PloS one, 2014 - journals.plos.org
The phosphoinositide-3-kinase (PI3K)/protein kinase B (Akt) axis plays a central role in
attenuating inflammation upon macrophage stimulation with toll-like receptor (TLR) ligands …
attenuating inflammation upon macrophage stimulation with toll-like receptor (TLR) ligands …
Targeting of Toll-like receptors: a decade of progress in combating infectious diseases
Toll-like receptors (TLRs) recognise highly conserved molecular structures, collectively
known as pathogen-associated molecular patterns. In the past two decades, development …
known as pathogen-associated molecular patterns. In the past two decades, development …
Toll-like receptor modulators: a patent review (2006–2010)
Introduction: The immune response is mediated via two parallel immune components, innate
and adaptive, whose effector functions are highly integrated and coordinated for the …
and adaptive, whose effector functions are highly integrated and coordinated for the …
Immunotoxicity of nanoparticles: A computational study suggests that CNTs and C 60 fullerenes might be recognized as pathogens by Toll-like receptors
M Turabekova, B Rasulev, M Theodore, J Jackman… - Nanoscale, 2014 - pubs.rsc.org
Over the last decade, a great deal of attention has been devoted to study the inflammatory
response upon exposure to multi/single-walled carbon nanotubes (CNTs) and different …
response upon exposure to multi/single-walled carbon nanotubes (CNTs) and different …
Novel drugs targeting Toll-like receptors for antiviral therapy
MC Patel, KA Shirey, LM Pletneva… - Future …, 2014 - Taylor & Francis
Toll-like receptors (TLRs) are sentinel receptors of the host innate immune system that
recognize conserved'pathogen-associated molecular patterns' of invading microbes …
recognize conserved'pathogen-associated molecular patterns' of invading microbes …
Advances in Toll-like receptor biology: Modes of activation by diverse stimuli
As we learn more about the biology of the Toll-like receptors (TLRs), a wide range of
molecules that can activate this fascinating family of pattern recognition receptors emerges …
molecules that can activate this fascinating family of pattern recognition receptors emerges …
Therapeutical targeting of nucleic acid-sensing Toll-like receptors prevents experimental cerebral malaria
BS Franklin, ST Ishizaka, M Lamphier… - Proceedings of the …, 2011 - National Acad Sciences
Excessive release of proinflammatory cytokines by innate immune cells is an important
component of the pathogenic basis of malaria. Proinflammatory cytokines are a direct output …
component of the pathogenic basis of malaria. Proinflammatory cytokines are a direct output …
Toll‐like receptors: role in dermatological disease
A Hari, TL Flach, Y Shi… - Mediators of inflammation, 2010 - Wiley Online Library
Toll‐like receptors (TLRs) are a class of conserved receptors that recognize pathogen‐
associated molecular patterns (PAMPs) present in microbes. In humans, at least ten TLRs …
associated molecular patterns (PAMPs) present in microbes. In humans, at least ten TLRs …